Chemoenzymatic Synthesis of 5-Methylpsilocybin: A Tryptamine with Potential Psychedelic Activity.

Animals Hallucinogens / chemical synthesis Mice Molecular Structure Psilocybe Psilocybin / analogs & derivatives Tryptamines / chemical synthesis

Journal

Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882

Informations de publication

Date de publication:
23 04 2021
Historique:
pubmed: 6 3 2021
medline: 15 12 2021
entrez: 5 3 2021
Statut: ppublish

Résumé

A novel analogue of psilocybin was produced by hybrid chemoenzymatic synthesis in sufficient quantity to enable bioassay. Utilizing purified 4-hydroxytryptamine kinase from

Identifiants

DOI: 10.1021/acs.jnatprod.1c00087 PMID: 33667102 PMC: PMC9191645
pubmed: 33667102
doi: 10.1021/acs.jnatprod.1c00087
pmc: PMC9191645
mid: NIHMS1802158
doi:

Substances chimiques

Hallucinogens 0
Tryptamines 0
Psilocybin 2RV7212BP0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1403-1408

Subventions

Organisme : NIDA NIH HHS
ID : R01 DA041336
Pays : United States

Références

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Auteurs

Janis Fricke (J)

Department Pharmaceutical Microbiology at the Hans-Knöll-Institute, Friedrich-Schiller-Universität Jena, Winzerlaer Strasse 2, 07745 Jena, Germany.

Alexander M Sherwood (AM)

Usona Institute, Madison Wisconsin 53711, United States.
ORCID: 0000-0003-0895-0791

Adam L Halberstadt (AL)

Department of Psychiatry, University of California San Diego, La Jolla, California 92093-0804, United States.
Research Service, VA San Diego Healthcare System, San Diego, California 92161, United States.
ORCID: 0000-0001-5096-5829

Robert B Kargbo (RB)

Usona Institute, Madison Wisconsin 53711, United States.

Dirk Hoffmeister (D)

Department Pharmaceutical Microbiology at the Hans-Knöll-Institute, Friedrich-Schiller-Universität Jena, Winzerlaer Strasse 2, 07745 Jena, Germany.
ORCID: 0000-0002-5302-6461

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chemoenzymatic Synthesis of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Hallucinogènes › Chemoenzymatic Synthesis of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Chemoenzymatic Synthesis of...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Chemoenzymatic Synthesis of...
questionsmedicales.fr › Eucaryotes › Champignons › Basidiomycota › Agaricales › Psilocybe › Chemoenzymatic Synthesis of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indolizine › Indolizidines › Alcaloïdes indoliques › Psilocybine › Chemoenzymatic Synthesis of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Tryptamines › Chemoenzymatic Synthesis of...