Assessment of the effect of therapy in a rat model of glioblastoma using [18F]FDG and [18F]FCho PET compared to contrast-enhanced MRI.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
20
11
2020
accepted:
19
02
2021
entrez:
5
3
2021
pubmed:
6
3
2021
medline:
12
10
2021
Statut:
epublish
Résumé
We investigated the potential of [18F]fluorodeoxyglucose ([18F]FDG) and [18F]Fluoromethylcholine ([18F]FCho) PET, compared to contrast-enhanced MRI, for the early detection of treatment response in F98 glioblastoma (GB) rats. When GB was confirmed on T2- and contrast-enhanced T1-weighted MRI, animals were randomized into a treatment group (n = 5) receiving MRI-guided 3D conformal arc micro-irradiation (20 Gy) with concomitant temozolomide, and a sham group (n = 5). Effect of treatment was evaluated by MRI and [18F]FDG PET on day 2, 5, 9 and 12 post-treatment and [18F]FCho PET on day 1, 6, 8 and 13 post-treatment. The metabolic tumor volume (MTV) was calculated using a semi-automatic thresholding method and the average tracer uptake within the MTV was converted to a standard uptake value (SUV). To detect treatment response, we found that for [18F]FDG PET (SUVmean x MTV) is superior to MTV only. Using (SUVmean x MTV), [18F]FDG PET detects treatment effect starting as soon as day 5 post-therapy, comparable to contrast-enhanced MRI. Importantly, [18F]FDG PET at delayed time intervals (240 min p.i.) was able to detect the treatment effect earlier, starting at day 2 post-irradiation. No significant differences were found at any time point for both the MTV and (SUVmean x MTV) of [18F]FCho PET. Both MRI and particularly delayed [18F]FDG PET were able to detect early treatment responses in GB rats, whereas, in this study this was not possible using [18F]FCho PET. Further comparative studies should corroborate these results and should also include (different) amino acid PET tracers.
Identifiants
pubmed: 33667282
doi: 10.1371/journal.pone.0248193
pii: PONE-D-20-36019
pmc: PMC7935304
doi:
Substances chimiques
Contrast Media
0
fluoromethylcholine
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
Choline
N91BDP6H0X
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0248193Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Neurosurg Rev. 2018 Jan;41(1):67-76
pubmed: 27230829
Eur J Nucl Med Mol Imaging. 2010 Nov;37(11):2188-93
pubmed: 20544193
Nucl Med Commun. 2017 Mar;38(3):242-249
pubmed: 27984537
J Nucl Med. 2002 Jan;43(1):92-6
pubmed: 11801711
Cancer Manag Res. 2014 Mar 24;6:149-70
pubmed: 24711712
Eur J Nucl Med Mol Imaging. 2020 Jun;47(6):1446-1457
pubmed: 31865407
Int J Cancer. 2001 Jun 20;96(3):191-7
pubmed: 11410888
Eur J Nucl Med Mol Imaging. 2006 Jul;33 Suppl 1:16-21
pubmed: 16763817
Eur J Nucl Med Mol Imaging. 2013 Jan;40(1):22-33
pubmed: 23053325
J Neurooncol. 2017 Sep;134(3):495-504
pubmed: 28382534
Radiology. 2007 Aug;244(2):557-65
pubmed: 17581887
J Nucl Med. 2018 Nov;59(11):1672-1678
pubmed: 29626123
J Nucl Med. 2011 Jun;52(6):865-72
pubmed: 21571807
Eur J Nucl Med Mol Imaging. 2002 Mar;29(3):319-23
pubmed: 12002705
J Neurooncol. 2009 Oct;95(1):87-93
pubmed: 19381442
Acta Neurochir (Wien). 2012 Feb;154(2):191-201; discussion 201
pubmed: 22130634
Neuroimage Clin. 2016 Dec 18;13:386-394
pubmed: 28116231
Eur Radiol. 2015 Oct;25(10):3017-24
pubmed: 25813014
J Neuroimaging. 2004 Jul;14(3):285-9
pubmed: 15228773
Semin Nucl Med. 2015 Mar;45(2):151-62
pubmed: 25704387
J Nucl Med. 2015 Mar;56(3):365-71
pubmed: 25678491
Neuro Oncol. 2016 Sep;18(9):1199-208
pubmed: 27106405
Lancet Neurol. 2010 Sep;9(9):906-20
pubmed: 20705518
Cancer Immunol Immunother. 2009 Oct;58(10):1627-34
pubmed: 19221744
EJNMMI Res. 2017 Dec;7(1):25
pubmed: 28324340
J Neurooncol. 2010 Oct;100(1):17-29
pubmed: 20179990
Nucl Med Biol. 2006 Apr;33(3):287-94
pubmed: 16631076
Clin Nucl Med. 2011 Nov;36(11):978-81
pubmed: 21975383
Neuro Oncol. 2020 Oct 30;22(12 Suppl 2):iv1-iv96
pubmed: 33123732
Front Neurol. 2016 Jul 28;7:120
pubmed: 27516754
Eur J Nucl Med. 2000 Jun;27(6):731-43
pubmed: 10901462
Clin Nucl Med. 2015 Jan;40(1):e40-5
pubmed: 25188640
J Neurosurg. 2019 Sep 1;131(3):657-666
pubmed: 31473668
Cancer Res. 2001 Jan 1;61(1):110-7
pubmed: 11196147
J Nucl Med. 2006 Feb;47(2):262-9
pubmed: 16455632
Semin Oncol. 2020 Apr - Jun;47(2-3):148-154
pubmed: 32513423
J Nucl Med. 2001 Dec;42(12):1805-14
pubmed: 11752077
Surgeon. 2014 Jun;12(3):148-57
pubmed: 24629841
PLoS One. 2016 Aug 25;11(8):e0161845
pubmed: 27559736
Cancers (Basel). 2019 Dec 07;11(12):
pubmed: 31817833
J Nucl Med. 2012 Jul;53(7):1048-57
pubmed: 22645298
Eur J Nucl Med. 2000 Jan;27(1):25-32
pubmed: 10654143
Nucl Med Biol. 2015 Jan;42(1):38-45
pubmed: 25218024
J Clin Oncol. 2017 Jul 20;35(21):2450-2456
pubmed: 28640704
Tumour Biol. 2014 Dec;35(12):12353-60
pubmed: 25182853
Br J Cancer. 2010 Aug 10;103(4):498-504
pubmed: 20628383
Ann Nucl Med. 2012 Jul;26(6):451-61
pubmed: 22566040
Lancet Oncol. 2017 Jun;18(6):e315-e329
pubmed: 28483413
J Neurooncol. 2014 Nov;120(2):257-66
pubmed: 25069566
Clin Nucl Med. 2013 Jul;38(7):495-500
pubmed: 23640217
Eur J Nucl Med Mol Imaging. 2004 Mar;31(3):317-24
pubmed: 14628097
J Clin Neurosci. 2008 May;15(5):545-51
pubmed: 18378459
Eur J Nucl Med Mol Imaging. 2005 Mar;32(3):294-301
pubmed: 15791438
Front Oncol. 2019 Aug 28;9:814
pubmed: 31555584
Curr Radiopharm. 2019;12(1):88-92
pubmed: 30117406
Hematol Oncol Clin North Am. 2012 Aug;26(4):825-53
pubmed: 22794286
J Nucl Med. 2004 Oct;45(10):1653-9
pubmed: 15471829
J Clin Oncol. 2010 Apr 10;28(11):1963-72
pubmed: 20231676
Phys Med Biol. 2012 Mar 21;57(6):1675-84
pubmed: 22398239
Int J Radiat Oncol Biol Phys. 2011 May 1;80(1):176-84
pubmed: 20646863
Acta Oncol. 2004;43(4):396-403
pubmed: 15303502
Nucl Med Commun. 2012 Sep;33(9):954-9
pubmed: 22842224
J Korean Neurosurg Soc. 2014 Jan;55(1):5-11
pubmed: 24570811
Neurooncol Adv. 2019 May 28;1(1):vdz010
pubmed: 32642650
J Nucl Med. 2008 May;49(5):730-7
pubmed: 18413396
Eur J Nucl Med Mol Imaging. 2008 Feb;35(2):253-63
pubmed: 17926036
Clin Positron Imaging. 2000 Jul;3(4):147
pubmed: 11150750
Discov Med. 2012 Jul;14(74):13-20
pubmed: 22846199
N Engl J Med. 2005 Mar 10;352(10):987-96
pubmed: 15758009
Am J Nucl Med Mol Imaging. 2014 Jun 07;4(4):365-84
pubmed: 24982822