Alzheimer's disease.
Journal
Lancet (London, England)
ISSN: 1474-547X
Titre abrégé: Lancet
Pays: England
ID NLM: 2985213R
Informations de publication
Date de publication:
24 04 2021
24 04 2021
Historique:
received:
26
04
2020
revised:
21
08
2020
accepted:
15
10
2020
pubmed:
6
3
2021
medline:
4
1
2022
entrez:
5
3
2021
Statut:
ppublish
Résumé
In this Seminar, we highlight the main developments in the field of Alzheimer's disease. The most recent data indicate that, by 2050, the prevalence of dementia will double in Europe and triple worldwide, and that estimate is 3 times higher when based on a biological (rather than clinical) definition of Alzheimer's disease. The earliest phase of Alzheimer's disease (cellular phase) happens in parallel with accumulating amyloid β, inducing the spread of tau pathology. The risk of Alzheimer's disease is 60-80% dependent on heritable factors, with more than 40 Alzheimer's disease-associated genetic risk loci already identified, of which the APOE alleles have the strongest association with the disease. Novel biomarkers include PET scans and plasma assays for amyloid β and phosphorylated tau, which show great promise for clinical and research use. Multidomain lifestyle-based prevention trials suggest cognitive benefits in participants with increased risk of dementia. Lifestyle factors do not directly affect Alzheimer's disease pathology, but can still contribute to a positive outcome in individuals with Alzheimer's disease. Promising pharmacological treatments are poised at advanced stages of clinical trials and include anti-amyloid β, anti-tau, and anti-inflammatory strategies.
Identifiants
pubmed: 33667416
pii: S0140-6736(20)32205-4
doi: 10.1016/S0140-6736(20)32205-4
pmc: PMC8354300
mid: NIHMS1717670
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1577-1590Subventions
Organisme : NIA NIH HHS
ID : P20 AG068053
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS093334
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072980
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM109025
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG053798
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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