Persistent Lung Inflammation After Clinical Resolution of Community-Acquired Pneumonia as Measured by

Aged Community-Acquired Infections / diagnostic imaging Disease Progression Female Fluorodeoxyglucose F18 Humans Male Pneumonia / diagnostic imaging Positron Emission Tomography Computed Tomography Radiopharmaceuticals Severity of Illness Index
community-acquired pneumonia survivors inflammation pneumonia pneumonia survivors

Journal

Chest
ISSN: 1931-3543
Titre abrégé: Chest
Pays: United States
ID NLM: 0231335

Informations de publication

Date de publication:
08 2021
Historique:
received: 19 10 2020
revised: 17 02 2021
accepted: 19 02 2021
pubmed: 6 3 2021
medline: 4 1 2022
entrez: 5 3 2021
Statut: ppublish

Résumé

Survivors of community-acquired pneumonia (CAP) are at increased risk of cardiovascular disease, cognitive and functional decline, and death, but the mechanisms remain unknown. Do CAP survivors have evidence of increased inflammatory activity in their lung parenchyma on 2-deoxy-2-[ We obtained Overall, 68% of CAP survivors (95% CI, 45%-85%) had distinct residual areas of increased An important proportion of CAP survivors have persistent pulmonary foci of increased inflammatory activity beyond resolution of their infection. As inflammation contributes to cardiovascular disease, cognitive decline, functional waning, and mortality risk in the general population, this finding provides a plausible mechanism for the increased morbidity and mortality that have been observed post-CAP.

Sections du résumé

BACKGROUND
Survivors of community-acquired pneumonia (CAP) are at increased risk of cardiovascular disease, cognitive and functional decline, and death, but the mechanisms remain unknown.
RESEARCH QUESTION
Do CAP survivors have evidence of increased inflammatory activity in their lung parenchyma on 2-deoxy-2-[
STUDY DESIGN AND METHODS
We obtained
RESULTS
Overall, 68% of CAP survivors (95% CI, 45%-85%) had distinct residual areas of increased
INTERPRETATION
An important proportion of CAP survivors have persistent pulmonary foci of increased inflammatory activity beyond resolution of their infection. As inflammation contributes to cardiovascular disease, cognitive decline, functional waning, and mortality risk in the general population, this finding provides a plausible mechanism for the increased morbidity and mortality that have been observed post-CAP.

Identifiants

DOI: 10.1016/j.chest.2021.02.048 PMID: 33667494 PMC: PMC8727848
pubmed: 33667494
pii: S0012-3692(21)00448-7
doi: 10.1016/j.chest.2021.02.048
pmc: PMC8727848
pii:
doi:

Substances chimiques

Radiopharmaceuticals 0
Fluorodeoxyglucose F18 0Z5B2CJX4D

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

446-453

Subventions

Organisme : NHLBI NIH HHS
ID : P01 HL094307
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL104106
Pays : United States
Organisme : NHLBI NIH HHS
ID : R61 HL146390
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL121510
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL136730
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG058969
Pays : United States

Informations de copyright

Copyright © 2021 American College of Chest Physicians. All rights reserved.

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Auteurs

Vicente F Corrales-Medina (VF)

Ottawa Hospital Research Institute, Ottawa, ON, Canada; Department of Medicine, University of Ottawa, ON, Canada.

Robert A deKemp (RA)

National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada; Division of Cardiology, Department of Medicine, University of Ottawa, ON, Canada.

Julio A Chirinos (JA)

University of Pennsylvania, Philadelphia, PA.

Wanzhen Zeng (W)

Department of Medicine, University of Ottawa, ON, Canada.

Jerry Wang (J)

National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada; Division of Cardiology, Department of Medicine, University of Ottawa, ON, Canada.

Grant Waterer (G)

Royal Perth Hospital, Perth, WA, Australia; School of Medicine, University of Western Australia, Perth, WA, Australia.

Rob S B Beanlands (RSB)

National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada; Division of Cardiology, Department of Medicine, University of Ottawa, ON, Canada.

Girish Dwivedi (G)

National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada; Division of Cardiology, Department of Medicine, University of Ottawa, ON, Canada; School of Medicine, University of Western Australia, Perth, WA, Australia; Department of Advanced Clinical and Translational Cardiovascular Imaging, Harry Perkins Institute of Medical Research, Murdoch, WA, Australia; Department of Cardiology, Fiona Stanley Hospital, Murdoch, WA, Australia. Electronic address: girish.dwivedi@perkins.uwa.edu.au.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Persistent Lung Inflammation After Clinical...
questionsmedicales.fr › Infection › Infections communautaires › Persistent Lung Inflammation After Clinical...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Persistent Lung Inflammation After Clinical...
questionsmedicales.fr › Glucides › Désoses › Désoxyglucose › Fluorodésoxyglucose F18 › Persistent Lung Inflammation After Clinical...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Persistent Lung Inflammation After Clinical...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Persistent Lung Inflammation After Clinical...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Tomographie par émission de positons couplée à la tomodensitométrie › Persistent Lung Inflammation After Clinical...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques › Persistent Lung Inflammation After Clinical...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Persistent Lung Inflammation After Clinical...