Selective Cardiomyocyte Oxidative Stress Leads to Bystander Senescence of Cardiac Stromal Cells.
CCR2+ Macrophages
SASP
cardiac mesenchymal stromal cells
monoamine oxidase A
oxidative stress
stress-induced premature senescence
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Feb 2021
24 Feb 2021
Historique:
received:
30
01
2021
revised:
17
02
2021
accepted:
19
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
30
4
2021
Statut:
epublish
Résumé
Accumulation of senescent cells in tissues during normal or accelerated aging has been shown to be detrimental and to favor the outcomes of age-related diseases such as heart failure (HF). We have previously shown that oxidative stress dependent on monoamine oxidase A (MAOA) activity in cardiomyocytes promotes mitochondrial damage, the formation of telomere-associated foci, senescence markers, and triggers systolic cardiac dysfunction in a model of transgenic mice overexpressing MAOA in cardiomyocytes (Tg MAOA). However, the impact of cardiomyocyte oxidative stress on the cardiac microenvironment in vivo is still unclear. Our results showed that systolic cardiac dysfunction in Tg MAOA mice was strongly correlated with oxidative stress induced premature senescence of cardiac stromal cells favoring the recruitment of CCR2
Identifiants
pubmed: 33668142
pii: ijms22052245
doi: 10.3390/ijms22052245
pmc: PMC7956294
pii:
doi:
Substances chimiques
Monoamine Oxidase
EC 1.4.3.4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Institut National de la Santé et de la Recherche Médicale
ID : ANR
Organisme : Fédération Française de Cardiologie
ID : fellowships and funding
Organisme : Conseil Régional Midi-Pyrénées
ID : APRTCN MiPy
Organisme : European Regional Development Fund
ID : program INSPIRE (FEDER-région Occitanie)
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