Prognostic Value of Apoptosis-Inducing Factor (AIF) in Germ Cell Tumors.
apoptosis
apoptosis inducing factor
prognosis
testicular germ cell tumors
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
13 Feb 2021
13 Feb 2021
Historique:
received:
20
01
2021
revised:
08
02
2021
accepted:
11
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
Apoptosis is a strictly regulated process essential for preservation of tissue homeostasis. This study aimed to evaluate expression of apoptosis inducing factor (AIF) in testicular germ cell tumors (GCTs) and to correlate expression patterns with clinicopathological variables. Formalin-fixed and paraffin-embedded specimens of non-neoplastic testicular tissue and GCTs obtained from 216 patients were included in the study. AIF expression was detected by immunohistochemistry, scored by the multiplicative quickscore method (QS). Normal testicular tissue exhibits higher cytoplasmic granular expression of AIF compared to GCTs (mean QS = 12.77 vs. 4.80,
Identifiants
pubmed: 33668443
pii: cancers13040776
doi: 10.3390/cancers13040776
pmc: PMC7917670
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : the VEGA Grant Agency of the Slovak Republic
ID : VEGA 1/0043/18
Organisme : the Slovak Research and Development Agency
ID : APVV-15-0086 and APVV-19-0411
Organisme : Ministry of Health
ID : MZ SR 2018/39-LFUK-13
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