Rutin and Gallic Acid Regulates Mitochondrial Functions via the SIRT1 Pathway in C2C12 Myotubes.
C2C12 myotubes
Sirtuin-1
gallic acid
mitochondria
rutin
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
13 Feb 2021
13 Feb 2021
Historique:
received:
22
01
2021
revised:
10
02
2021
accepted:
10
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
Mitochondria are highly dynamic organelles, balancing synthesis and degradation in response to increases in mitochondrial turnover (i.e., biogenesis, fusion, fission, and mitophagy) and function. The aim of this study was to investigate the role of polyphenols in the regulation of mitochondrial functions and dynamics in C2C12 myotubes and their molecular mechanisms. Our results indicate that gallic acid and rutin are the most potential polyphenol compounds in response to 15 phenolic acids and 5 flavonoids. Gallic acid and rutin were associated with a significantly greater mitochondrial DNA (
Identifiants
pubmed: 33668647
pii: antiox10020286
doi: 10.3390/antiox10020286
pmc: PMC7918168
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : This research work was partially funded by the Ministry of Science and Technology, Taiwan, Republic of China.
ID : MOST 107-2320-B-040-019-MY3
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