Polymeric Micelles in Cancer Immunotherapy.
cancer immunotherapy
micelles
polymeric nanoparticles
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
25 Feb 2021
25 Feb 2021
Historique:
received:
30
11
2020
revised:
19
02
2021
accepted:
22
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
10
4
2021
Statut:
epublish
Résumé
Cancer immunotherapies have generated some miracles in the clinic by orchestrating our immune system to combat cancer cells. However, the safety and efficacy concerns of the systemic delivery of these immunostimulatory agents has limited their application. Nanomedicine-based delivery strategies (e.g., liposomes, polymeric nanoparticles, silico, etc.) play an essential role in improving cancer immunotherapies, either by enhancing the anti-tumor immune response, or reducing their systemic adverse effects. The versatility of working with biocompatible polymers helps these polymeric nanoparticles stand out as a key carrier to improve bioavailability and achieve specific delivery at the site of action. This review provides a summary of the latest advancements in the use of polymeric micelles for cancer immunotherapy, including their application in delivering immunological checkpoint inhibitors, immunostimulatory molecules, engineered T cells, and cancer vaccines.
Identifiants
pubmed: 33668746
pii: molecules26051220
doi: 10.3390/molecules26051220
pmc: PMC7956602
pii:
doi:
Substances chimiques
Micelles
0
Polymers
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 32001002
Organisme : National Key R&D Program of China
ID : 2017YFA0105802, 2020YFF0426289
Organisme : Sichuan Science and Technology Program
ID : 2020YFH0008
Références
Br J Anaesth. 2020 Mar;124(3):251-260
pubmed: 32007241
Trends Immunol. 2011 Apr;32(4):180-6
pubmed: 21371940
Clin Cancer Res. 2016 May 1;22(9):2155-66
pubmed: 26712687
Eur J Pharm Sci. 2016 Feb 15;83:184-202
pubmed: 26747018
N Engl J Med. 2018 Feb 1;378(5):439-448
pubmed: 29385370
Biomater Sci. 2019 Jun 25;7(7):3062-3075
pubmed: 31140475
Allergol Immunopathol (Madr). 2001 Nov-Dec;29(6):245-54
pubmed: 11834183
Nat Med. 2013 Nov;19(11):1534-41
pubmed: 24121928
Jpn J Med. 1988 Feb;27(1):71-3
pubmed: 3285063
Br J Cancer. 2019 Jan;120(1):6-15
pubmed: 30413827
J Control Release. 2015 Feb 28;200:1-12
pubmed: 25540903
Crit Care Med. 2017 Feb;45(2):e124-e131
pubmed: 27632680
Int J Womens Health. 2014 Dec 03;6:999-1010
pubmed: 25587221
Sci Transl Med. 2012 May 2;4(132):132ra53
pubmed: 22553251
J Control Release. 2017 Sep 10;261:352-366
pubmed: 28163211
Nat Rev Immunol. 2003 Feb;3(2):133-46
pubmed: 12563297
Clin Cancer Res. 2018 Feb 1;24(3):535-540
pubmed: 29158268
ACS Nano. 2017 Mar 28;11(3):2387-2392
pubmed: 28277646
Nat Med. 2004 Sep;10(9):909-15
pubmed: 15340416
Cell. 2010 Apr 2;141(1):39-51
pubmed: 20371344
J Adv Res. 2018 Jun 25;15:1-18
pubmed: 30581608
Sci Transl Med. 2013 Aug 7;5(197):197ra103
pubmed: 23926201
PLoS One. 2014 Jul 11;9(7):e101854
pubmed: 25013909
Biochem Pharmacol. 2021 Feb 3;:114453
pubmed: 33545119
Acta Biomater. 2019 May;90:300-313
pubmed: 30930305
Biomaterials. 2007 Feb;28(6):994-1004
pubmed: 17118442
Front Immunol. 2020 Feb 18;11:188
pubmed: 32133000
J Hematol Oncol. 2018 Mar 15;11(1):39
pubmed: 29544515
Adv Drug Deliv Rev. 2005 Jan 10;57(3):333-55
pubmed: 15560945
Pharmacol Ther. 2006 Dec;112(3):630-48
pubmed: 16815554
Biomaterials. 2017 Apr;122:105-113
pubmed: 28110170
Nat Rev Immunol. 2002 Sep;2(9):675-87
pubmed: 12209136
Int J Nanomedicine. 2018 May 18;13:2921-2942
pubmed: 29849457
Theranostics. 2019 Oct 15;9(25):7826-7848
pubmed: 31695803
Nat Commun. 2017 Nov 23;8(1):1738
pubmed: 29170503
J Control Release. 2015 May 28;206:220-31
pubmed: 25819159
J Control Release. 2016 Jun 10;231:17-28
pubmed: 26829099
Cancers (Basel). 2016 Nov 24;8(12):
pubmed: 27886124
J Control Release. 2013 Sep 10;170(2):259-67
pubmed: 23742880
Oncologist. 2016 Jul;21(7):804-16
pubmed: 27306911
Biomaterials. 2016 Sep;101:296-309
pubmed: 27315213
J Hematol Oncol. 2019 Sep 5;12(1):92
pubmed: 31488176
J Drug Target. 2018 Nov;26(9):753-765
pubmed: 29256633
ACS Appl Mater Interfaces. 2020 Oct 14;12(41):45873-45890
pubmed: 32924511
Nano Res. 2018 Oct;11(10):4985-4998
pubmed: 30370014
Aliment Pharmacol Ther. 2019 Oct;50(8):872-884
pubmed: 31378985
Mol Ther. 2016 Feb;24(2):364-374
pubmed: 26334519
Int Immunopharmacol. 2014 Dec;23(2):499-504
pubmed: 25284343
J Drug Target. 2018 Apr;26(4):311-318
pubmed: 28797169
Biomaterials. 2015 Jan;38:50-60
pubmed: 25457983
J Control Release. 2004 Apr 28;96(2):273-83
pubmed: 15081218
Mol Ther Methods Clin Dev. 2016 Dec 31;4:92-101
pubmed: 28344995
Sci Adv. 2020 Mar 18;6(12):eaaw6071
pubmed: 32206706
Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7119-24
pubmed: 19359475
J Clin Oncol. 2016 Oct 10;34(29):3576-3578
pubmed: 27573656
RNA Biol. 2012 Nov;9(11):1319-30
pubmed: 23064118
Nat Immunol. 2010 May;11(5):373-84
pubmed: 20404851
Biomacromolecules. 2015 Nov 9;16(11):3666-73
pubmed: 26473322
ACS Appl Mater Interfaces. 2020 Jul 15;12(28):31904-31921
pubmed: 32551517
Nature. 2001 Oct 18;413(6857):732-8
pubmed: 11607032
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017 Sep;9(5):
pubmed: 28296286
Chem Soc Rev. 2011 Jan;40(1):320-39
pubmed: 21060941
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1476-1487
pubmed: 31070063
Cancer Discov. 2018 Sep;8(9):1069-1086
pubmed: 30115704
Eur J Pharm Biopharm. 2016 May;102:20-31
pubmed: 26940132
Trends Immunol. 2017 Aug;38(8):577-593
pubmed: 28610825
Hum Vaccin Immunother. 2014;10(11):3153-64
pubmed: 25625927
J Immunol. 2015 Aug 15;195(4):1341-9
pubmed: 26254266
Oncoimmunology. 2019 Sep 20;8(12):e1659096
pubmed: 31741757
Cell Discov. 2017 Apr 04;3:17007
pubmed: 28417012
Nanomaterials (Basel). 2019 May 09;9(5):
pubmed: 31075929
Langmuir. 2005 Mar 29;21(7):2668-74
pubmed: 15779933
Cells. 2020 Sep 09;9(9):
pubmed: 32917034
Int J Nanomedicine. 2020 Feb 04;15:779-793
pubmed: 32099365
Nat Nanotechnol. 2017 Sep;12(9):877-882
pubmed: 28650437
Acta Pharm Sin B. 2019 Jul;9(4):819-831
pubmed: 31384541
Ann Oncol. 2017 Dec 1;28(suppl_12):xii11-xii17
pubmed: 29253113
Nat Rev Clin Oncol. 2018 Apr;15(4):234-248
pubmed: 29405201
Adv Cancer Res. 2013;119:421-75
pubmed: 23870514
Cell. 2017 Feb 9;168(4):724-740
pubmed: 28187291
J Am Acad Dermatol. 2014 Jun;70(6):979.e1-12; quiz 9912
pubmed: 24831325
J Leukoc Biol. 2021 Feb;109(2):425-436
pubmed: 33259068
Trends Microbiol. 2017 Nov;25(11):906-918
pubmed: 28625530
Cancer Immunol Immunother. 2020 Jul;69(7):1375-1387
pubmed: 32078016
Nat Rev Drug Discov. 2016 Sep 29;15(10):663-5
pubmed: 27681782
J Control Release. 2016 Oct 28;240:227-234
pubmed: 26718856
Cutis. 2015 Oct;96(4):277-82
pubmed: 26682290
ACS Appl Mater Interfaces. 2018 Jan 24;10(3):2874-2889
pubmed: 29285934
Immunity. 2016 Jun 21;44(6):1444-54
pubmed: 27332733
Nat Commun. 2016 Nov 07;7:13443
pubmed: 27819653
J Control Release. 2017 Jan 10;245:81-94
pubmed: 27863995
J Immunol Res. 2016;2016:1459394
pubmed: 27274998
Biomacromolecules. 2015 Sep 14;16(9):2693-700
pubmed: 26207413
Adv Sci (Weinh). 2018 Feb 26;5(5):1700891
pubmed: 29876215
Chem Biol Interact. 2018 Nov 1;295:20-37
pubmed: 30036501
Cytokine Growth Factor Rev. 2014 Dec;25(6):681-97
pubmed: 25070125
Expert Opin Drug Deliv. 2018 Nov;15(11):1127-1142
pubmed: 30324813
Vaccines (Basel). 2020 Mar 20;8(1):
pubmed: 32244935
Science. 2007 Jun 15;316(5831):1628-32
pubmed: 17569868
Acta Pharmacol Sin. 2017 Jun;38(6):823-834
pubmed: 28504251
Iowa Orthop J. 2006;26:154-8
pubmed: 16789469
Nat Rev Drug Discov. 2018 Apr;17(4):261-279
pubmed: 29326426
Adv Healthc Mater. 2020 Jan;9(1):e1901223
pubmed: 31794153
Colloids Surf B Biointerfaces. 2019 Jan 1;173:581-590
pubmed: 30352379
Vaccine. 2007 Jan 8;25(4):763-75
pubmed: 16968658
ACS Nano. 2019 Aug 27;13(8):8648-8658
pubmed: 31328920
J Med Chem. 2010 Jun 10;53(11):4450-65
pubmed: 20481492
Biomater Sci. 2019 Jun 25;7(7):2769-2776
pubmed: 31012882
Adv Drug Deliv Rev. 2017 May 15;114:79-101
pubmed: 28545888
Curr Opin Biotechnol. 2020 Dec;66:113-122
pubmed: 32745889
J Biol Chem. 2003 Mar 14;278(11):8869-72
pubmed: 12527755
Nano Lett. 2016 Apr 13;16(4):2512-21
pubmed: 27022664
Eur J Immunol. 2004 Jan;34(1):251-62
pubmed: 14971051
Macromol Biosci. 2017 Jan;17(1):
pubmed: 27413999
Acta Pharmacol Sin. 2020 Jul;41(7):911-927
pubmed: 32123302
J Biomed Nanotechnol. 2018 Sep 1;14(9):1613-1626
pubmed: 29958555
Cold Spring Harb Perspect Biol. 2018 Dec 3;10(12):
pubmed: 29101107
Biomaterials. 2018 Apr;161:33-46
pubmed: 29421561
Nat Biotechnol. 2008 Jul;26(7):799-807
pubmed: 18587385
Cancers (Basel). 2011 Oct 13;3(4):3856-93
pubmed: 24213115
Oncotarget. 2016 Sep 20;7(38):62607-62618
pubmed: 27566585
NPJ Vaccines. 2019 Feb 8;4:7
pubmed: 30774998
Nature. 2011 Dec 21;480(7378):480-9
pubmed: 22193102
Sci Transl Med. 2017 Jul 19;9(399):
pubmed: 28724573
Sci Adv. 2020 Jun 17;6(25):eaba5542
pubmed: 32596460
Cancers (Basel). 2020 Mar 20;12(3):
pubmed: 32245016
Adv Healthc Mater. 2019 Feb;8(4):e1801320
pubmed: 30666822
PLoS Pathog. 2009 Apr;5(4):e1000373
pubmed: 19360120
Nat Rev Immunol. 2004 Jul;4(7):499-511
pubmed: 15229469
Nat Rev Drug Discov. 2003 May;2(5):347-60
pubmed: 12750738
Immunity. 2013 Jul 25;39(1):1-10
pubmed: 23890059
Best Pract Res Clin Haematol. 2003 Mar;16(1):69-81
pubmed: 12670466
Nat Rev Clin Oncol. 2018 Jan;15(1):47-62
pubmed: 28925994
J Immunother Cancer. 2017 Mar 21;5:22
pubmed: 28344808
J Biomed Nanotechnol. 2018 Oct 1;14(10):1719-1730
pubmed: 30041719
Immunol Rev. 2011 Jan;239(1):62-84
pubmed: 21198665
Nature. 2017 Jan 18;541(7637):321-330
pubmed: 28102259
Nano Lett. 2005 Feb;5(2):315-9
pubmed: 15794618
Sci Technol Adv Mater. 2019 Apr 15;20(1):324-336
pubmed: 31068982
ACS Nano. 2013 May 28;7(5):3912-25
pubmed: 23590591
Nat Commun. 2017 Dec 6;8(1):1961
pubmed: 29213079
Oncol Res. 2014;21(5):227-35
pubmed: 24854099
J Immunol. 2010 Jun 15;184(12):7022-9
pubmed: 20488791
Science. 2020 Aug 21;369(6506):
pubmed: 32820094
Hum Vaccin Immunother. 2014;10(1):52-63
pubmed: 24064957
Clin Cosmet Investig Dermatol. 2011;4:35-40
pubmed: 21691565
Cancer Chemother Pharmacol. 2017 Apr;79(4):637-649
pubmed: 28314988
Blood. 2013 Aug 8;122(6):863-71
pubmed: 23770775
Eur J Pharm Biopharm. 2017 Apr;113:211-228
pubmed: 28087380
Science. 2013 Sep 20;341(6152):1390-4
pubmed: 23989956
Biomaterials. 2019 Feb;192:1-14
pubmed: 30415101
Immunotherapy. 2017 Mar;9(4):347-360
pubmed: 28303764
Adv Sci (Weinh). 2019 Jun 21;6(17):1900101
pubmed: 31508270
P T. 2017 Aug;42(8):514-521
pubmed: 28781505
Nat Rev Immunol. 2002 Apr;2(4):251-62
pubmed: 12001996
Semin Oncol. 1998 Dec;25(6):623-35
pubmed: 9865677
Clin Adv Hematol Oncol. 2016 Oct;14(10):802-808
pubmed: 27930631
N Engl J Med. 2017 Dec 28;377(26):2531-2544
pubmed: 29226797
Small. 2020 Feb;16(7):e1906832
pubmed: 31990457
Nature. 2011 Sep 25;478(7370):515-8
pubmed: 21947006
Vaccines (Basel). 2015 Apr 23;3(2):344-72
pubmed: 26343191
Mol Cancer. 2019 Aug 23;18(1):128
pubmed: 31443694
Theranostics. 2017 Sep 26;7(18):4383-4398
pubmed: 29158834
Immunol Rev. 2011 Jan;239(1):178-96
pubmed: 21198672
CA Cancer J Clin. 2020 Mar;70(2):86-104
pubmed: 31944278
J Control Release. 2019 Nov 10;313:42-53
pubmed: 31629039