MicroRNA-mRNA Networks in Pregnancy Complications: A Comprehensive Downstream Analysis of Potential Biomarkers.
Biomarkers
/ blood
Female
Fetal Growth Retardation
/ genetics
Gene Ontology
Humans
MicroRNAs
/ genetics
Placenta Diseases
/ genetics
Placentation
/ genetics
Pre-Eclampsia
/ genetics
Pregnancy
Pregnancy Complications
/ genetics
RNA, Messenger
/ genetics
Signal Transduction
/ genetics
Transcriptome
/ genetics
biomarkers
intrauterine growth restriction
miR-210
miRNAs
preeclampsia
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Feb 2021
25 Feb 2021
Historique:
received:
12
01
2021
revised:
22
02
2021
accepted:
23
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
4
5
2021
Statut:
epublish
Résumé
Pregnancy complications are a major cause of fetal and maternal morbidity and mortality in humans. The majority of pregnancy complications initiate due to abnormal placental development and function. During the last decade, the role of microRNAs (miRNAs) in regulating placental and fetal development has become evident. Dysregulation of miRNAs in the placenta not only affects placental development and function, but these miRNAs can also be exported to both maternal and fetal compartments and affect maternal physiology and fetal growth and development. Due to their differential expression in the placenta and maternal circulation during pregnancy complications, miRNAs can be used as diagnostic biomarkers. However, the differential expression of a miRNA in the placenta may not always be reflected in maternal circulation, which makes it difficult to find a reliable biomarker for placental dysfunction. In this review, we provide an overview of differentially expressed miRNAs in the placenta and/or maternal circulation during preeclampsia (PE) and intrauterine growth restriction (IUGR), which can potentially serve as biomarkers for prediction or diagnosis of pregnancy complications. Using different bioinformatics tools, we also identified potential target genes of miRNAs associated with PE and IUGR, and the role of miRNA-mRNA networks in the regulation of important signaling pathways and biological processes.
Identifiants
pubmed: 33669156
pii: ijms22052313
doi: 10.3390/ijms22052313
pmc: PMC7956714
pii:
doi:
Substances chimiques
Biomarkers
0
MIRN210 microRNA, human
0
MicroRNAs
0
RNA, Messenger
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Pregnancy. 2017;2017:6972732
pubmed: 28713594
BMJ. 2019 Jul 15;366:l2381
pubmed: 31307997
Development. 2014 Apr;141(8):1614-26
pubmed: 24715453
Anticancer Res. 2017 Dec;37(12):6511-6521
pubmed: 29187425
Clin Transl Med. 2020 Jan 28;9(1):9
pubmed: 31993806
Biochim Biophys Acta. 2010 Dec;1806(2):200-7
pubmed: 20637263
Fetal Diagn Ther. 2020;47(9):665-674
pubmed: 32585676
Am J Obstet Gynecol. 2018 Feb;218(2S):S790-S802.e1
pubmed: 29422212
RNA. 2004 Oct;10(10):1507-17
pubmed: 15383676
J Obstet Gynaecol Res. 2018 Apr;44(4):756-763
pubmed: 29345032
Genet Mol Res. 2011 Nov 08;10(4):4034-40
pubmed: 22095477
Histol Histopathol. 2007 Mar;22(3):227-34
pubmed: 17163397
J Cell Mol Med. 2019 Jun;23(6):4422-4433
pubmed: 30993882
Pregnancy Hypertens. 2020 Jan;19:159-168
pubmed: 32014817
J Clin Endocrinol Metab. 2012 Jun;97(6):E1051-9
pubmed: 22438230
J Matern Fetal Neonatal Med. 2019 Mar 28;:1-8
pubmed: 30922130
Neuro Endocrinol Lett. 2015 Dec;36(7):695-9
pubmed: 26859593
Prenat Diagn. 2013 Mar;33(3):214-22
pubmed: 23354729
Placenta. 2018 Jan;61:61-71
pubmed: 29277273
Placenta. 2020 Mar;92:44-53
pubmed: 32063549
Eur Rev Med Pharmacol Sci. 2018 Mar;22(6):1533-1540
pubmed: 29630094
Sci Rep. 2014 May 08;4:4882
pubmed: 24811064
Oncotarget. 2017 Nov 9;8(63):107167-107175
pubmed: 29291020
Pregnancy Hypertens. 2014 Jan;4(1):11-3
pubmed: 26104247
Bioinformatics. 2009 Apr 15;25(8):1091-3
pubmed: 19237447
Reproduction. 2018 Jun;155(6):R259-R271
pubmed: 29615475
J Clin Endocrinol Metab. 2017 Sep 1;102(9):3182-3194
pubmed: 28531338
PLoS One. 2017 Feb 9;12(2):e0171756
pubmed: 28182660
Cell Signal. 2019 Mar;55:40-52
pubmed: 30552989
Curr Opin Chem Biol. 2019 Aug;51:11-17
pubmed: 30825741
Database (Oxford). 2015;2015:
pubmed: 26490638
Diagn Pathol. 2010 Apr 22;5:24
pubmed: 20412591
Am J Obstet Gynecol. 2009 Jun;200(6):661.e1-7
pubmed: 19285651
Int J Mol Sci. 2020 May 21;21(10):
pubmed: 32455665
Mol Med Rep. 2019 Feb;19(2):1150-1158
pubmed: 30569125
Cell Death Dis. 2018 Jan 16;9(2):16
pubmed: 29339719
Proc Natl Acad Sci U S A. 2014 May 20;111(20):7361-6
pubmed: 24799715
Placenta. 2018 Jan;61:24-32
pubmed: 29277268
Gene. 2019 Apr 15;692:138-144
pubmed: 30659946
J Mol Histol. 2018 Jun;49(3):317-327
pubmed: 29603045
FASEB J. 2017 Jul;31(7):2760-2770
pubmed: 28289056
Transl Res. 2016 Jun;172:61-72
pubmed: 27012474
J Pregnancy. 2012;2012:179827
pubmed: 23304511
Sci Rep. 2020 Sep 30;10(1):16142
pubmed: 32999354
Mol Med Rep. 2017 Aug;16(2):1007-1013
pubmed: 29067442
Nat Biotechnol. 2010 Dec;28(12):1248-50
pubmed: 21139605
Sci Rep. 2018 Mar 23;8(1):5142
pubmed: 29572450
Sci Rep. 2018 Feb 21;8(1):3401
pubmed: 29467498
Theriogenology. 2020 Feb;143:98-112
pubmed: 31864010
Eur J Obstet Gynecol Reprod Biol. 2013 Sep;170(1):96-9
pubmed: 23810060
PLoS One. 2013;8(3):e58737
pubmed: 23554918
Biomed Res Int. 2015;2015:294954
pubmed: 25699269
Pregnancy Hypertens. 2019 Jan;15:201-208
pubmed: 30713088
Pediatr Res. 2018 Jan;83(1-1):183-189
pubmed: 28910276
Placenta. 2019 Jun;81:46-53
pubmed: 31138431
Placenta. 2017 Mar;51:70-75
pubmed: 28292471
Placenta. 2013 Sep;34(9):799-804
pubmed: 23830491
J Transl Med. 2020 Jan 22;18(1):32
pubmed: 31969163
Nat Protoc. 2013 Aug;8(8):1551-66
pubmed: 23868073
J Obstet Gynaecol Res. 2015 Oct;41(10):1526-32
pubmed: 26224638
PLoS One. 2015 Sep 22;10(9):e0138383
pubmed: 26394310
Stem Cells Int. 2018 Mar 15;2018:4217259
pubmed: 29736175
Bioinformatics. 2013 Mar 1;29(5):661-3
pubmed: 23325622
Vaccine. 2017 Dec 4;35(48 Pt A):6546-6554
pubmed: 29150060
Reproduction. 2012 Mar;143(3):389-97
pubmed: 22187671
EBioMedicine. 2020 Dec;62:103145
pubmed: 33260001
Sci Rep. 2017 Nov 29;7(1):16548
pubmed: 29185488
Mol Med Rep. 2017 Nov;16(5):6650-6673
pubmed: 28901463
Reprod Toxicol. 2021 Jan;99:168-176
pubmed: 33049332
Biochem Biophys Res Commun. 2014 Oct 10;453(1):57-63
pubmed: 25251470
J Hum Hypertens. 2014 Oct;28(10):610-6
pubmed: 24804790
Biol Reprod. 2020 Aug 21;103(3):471-486
pubmed: 32401303
Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3099-3108
pubmed: 29859241
Biol Reprod. 2009 Oct;81(4):717-29
pubmed: 19494253
Gene. 2019 Jan 30;683:225-232
pubmed: 30315928
Am J Physiol Cell Physiol. 2009 Jul;297(1):C4-5
pubmed: 19439527
Mol Ther. 2018 Sep 5;26(9):2189-2205
pubmed: 30061037
BMC Syst Biol. 2018 Dec 27;12(1):145
pubmed: 30591051
Am J Obstet Gynecol. 2011 Feb;204(2):178.e12-21
pubmed: 21093846
FASEB J. 2019 Nov;33(11):12348-12363
pubmed: 31415216
Genes Dev. 2016 Nov 15;30(22):2459-2474
pubmed: 27940961
Fertil Steril. 2016 May;105(5):1247-1254.e3
pubmed: 26868995
Medicine (Baltimore). 2017 Jul;96(28):e7515
pubmed: 28700503
BMJ. 1995 Jul 15;311(6998):171-4
pubmed: 7613432
J Matern Fetal Neonatal Med. 2020 Mar;33(6):901-908
pubmed: 30078346
Front Endocrinol (Lausanne). 2018 Aug 03;9:402
pubmed: 30123182
Pregnancy Hypertens. 2019 Apr;16:120-125
pubmed: 31056146
Int J Mol Sci. 2014 Sep 12;15(9):16153-85
pubmed: 25222554
Med Princ Pract. 2019;28(2):101-108
pubmed: 30685759
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
BMC Med Genomics. 2019 Jun 27;12(1):91
pubmed: 31248403
J Cell Sci. 2004 Mar 15;117(Pt 8):1281-3
pubmed: 15020666
Placenta. 2019 Aug;83:57-62
pubmed: 31477209
Chem Biol Interact. 2019 Jan 25;298:8-14
pubmed: 30367833
J Cell Biochem. 2018 Jan;119(1):1141-1151
pubmed: 28703916
Arch Biochem Biophys. 2018 Dec 1;659:13-21
pubmed: 30261165
Placenta. 2002 Jan;23(1):3-19
pubmed: 11869088
Biomed Res Int. 2013;2013:970265
pubmed: 24195082
J Reprod Immunol. 2011 May;89(2):185-91
pubmed: 21513988
Placenta. 2013 Jul;34(7):624-7
pubmed: 23643257
PLoS One. 2017 May 2;12(5):e0176493
pubmed: 28463968
Biomed Rep. 2015 Nov;3(6):792-796
pubmed: 26623017
Am J Obstet Gynecol. 2018 Feb;218(2):249.e1-249.e12
pubmed: 29155142
Arch Gynecol Obstet. 2018 Feb;297(2):365-371
pubmed: 29196869
Nutr Metab (Lond). 2020 Jul 6;17:52
pubmed: 32655673
Int J Mol Sci. 2019 Jun 18;20(12):
pubmed: 31216670
Pregnancy Hypertens. 2012 Apr 1;2(2):72-83
pubmed: 22745921
Eur J Obstet Gynecol Reprod Biol. 2015 Oct;193:10-8
pubmed: 26207980
Genet Test Mol Biomarkers. 2020 Jun;24(6):321-327
pubmed: 32511062
Mol Nutr Food Res. 2017 Aug;61(8):
pubmed: 28105727
Taiwan J Obstet Gynecol. 2014 Jun;53(2):232-4
pubmed: 25017274
PLoS One. 2012;7(6):e38875
pubmed: 22723898
Sci Rep. 2016 Jan 29;6:19910
pubmed: 26822621
Eur Rev Med Pharmacol Sci. 2018 Oct;22(20):6599-6608
pubmed: 30402831
Gene. 2017 Sep 5;627:543-548
pubmed: 28694210
J Int Med Res. 2014 Dec;42(6):1243-51
pubmed: 25341970
Cardiovasc J Afr. 2016 Mar-Apr;27(2):71-8
pubmed: 27213853
Sci Rep. 2017 Jul 17;7(1):5548
pubmed: 28717128
Placenta. 2017 Feb;50:102-109
pubmed: 28161054
Nat Rev Genet. 2015 Feb;16(2):113-26
pubmed: 25488579
Development. 2019 Nov 27;146(22):
pubmed: 31776138
Birth Defects Res. 2017 Oct 16;109(17):1309-1329
pubmed: 29105383
Am J Pathol. 2013 Apr;182(4):1448-58
pubmed: 23410520
Biomed Pharmacother. 2018 Nov;107:746-753
pubmed: 30138897
PLoS One. 2017 Mar 28;12(3):e0174514
pubmed: 28350871
Am J Perinatol. 2014 Oct;31(9):729-34
pubmed: 24683074
Physiol Rev. 2016 Oct;96(4):1509-65
pubmed: 27604528
Clin Chem. 2010 Nov;56(11):1767-71
pubmed: 20729298
Thromb Res. 2004;114(5-6):397-407
pubmed: 15507270
Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20354-20356
pubmed: 32788372
PeerJ. 2017 Aug 14;5:e3682
pubmed: 28828274
Eur Rev Med Pharmacol Sci. 2018 Apr;22(8):2199-2206
pubmed: 29762819
Hypertens Pregnancy. 2014 May;33(2):215-35
pubmed: 24304191
Medicine (Baltimore). 2020 Feb;99(7):e18897
pubmed: 32049790
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W451-4
pubmed: 16845047
Int J Mol Sci. 2016 Nov 28;17(12):
pubmed: 27916805
Clin Obstet Gynecol. 2006 Jun;49(2):270-83
pubmed: 16721106
Toxicol Rep. 2020 Aug 15;7:1046-1056
pubmed: 32913718
Biol Reprod. 2021 Feb 11;104(2):418-429
pubmed: 33074310
Semin Perinatol. 2004 Feb;28(1):67-80
pubmed: 15058904
Hypertension. 2014 Jun;63(6):1276-84
pubmed: 24664294
Clin Chem Lab Med. 2009;47(8):923-9
pubmed: 19642860
Am J Obstet Gynecol. 2007 Mar;196(3):261.e1-6
pubmed: 17346547
Clin Chim Acta. 2011 Nov 20;412(23-24):2167-73
pubmed: 21840305
Genes Dev. 2008 May 15;22(10):1276-312
pubmed: 18483217
Placenta. 2010 Sep;31(9):781-4
pubmed: 20667590
Semin Perinatol. 2006 Feb;30(1):16-9
pubmed: 16549208
Elife. 2015 Aug 12;4:
pubmed: 26267216