Precision Medicine and Public Health: New Challenges for Effective and Sustainable Health.
early disease prevention
epigenetic modulations
genetic and microbiome markers
genetic polymorphisms
health technology assessment
miRNA
public health genomics
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
16 Feb 2021
16 Feb 2021
Historique:
received:
18
12
2020
revised:
11
02
2021
accepted:
14
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
The development of high-throughput omics technologies represents an unmissable opportunity for evidence-based prevention of adverse effects on human health. However, the applicability and access to multi-omics tests are limited. In Italy, this is due to the rapid increase of knowledge and the high levels of skill and economic investment initially necessary. The fields of human genetics and public health have highlighted the relevance of an implementation strategy at a national level in Italy, including integration in sanitary regulations and governance instruments. In this review, the emerging field of public health genomics is discussed, including the polygenic scores approach, epigenetic modulation, nutrigenomics, and microbiomes implications. Moreover, the Italian state of implementation is presented. The omics sciences have important implications for the prevention of both communicable and noncommunicable diseases, especially because they can be used to assess the health status during the whole course of life. An effective population health gain is possible if omics tools are implemented for each person after a preliminary assessment of effectiveness in the medium to long term.
Identifiants
pubmed: 33669364
pii: jpm11020135
doi: 10.3390/jpm11020135
pmc: PMC7920275
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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