The Role of Bcl-xL Protein in Viral Infections.
Bcl-xL
CoV
EBV
HBV
HCV
HIV
HTLV-1
IAV
MRBV
SBV
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Feb 2021
16 Feb 2021
Historique:
received:
28
01
2021
revised:
13
02
2021
accepted:
14
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
19
3
2021
Statut:
epublish
Résumé
Bcl-xL represents a family of proteins responsible for the regulation of the intrinsic apoptosis pathway. Due to its anti-apoptotic activity, Bcl-xL co-determines the viability of various virally infected cells. Their survival may determine the effectiveness of viral replication and spread, dynamics of systemic infection, and viral pathogenesis. In this paper, we have reviewed the role of Bcl-xL in the context of host infection by eight different RNA and DNA viruses: hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), influenza A virus (IAV), Epstein-Barr virus (EBV), human T-lymphotropic virus type-1 (HTLV-1), Maraba virus (MRBV), Schmallenberg virus (SBV) and coronavirus (CoV). We have described an influence of viral infection on the intracellular level of Bcl-xL and discussed the impact of Bcl-xL-dependent cell survival control on infection-accompanying pathogenic events such as tissue damage or oncogenesis. We have also presented anti-viral treatment strategies based on the pharmacological regulation of Bcl-xL expression or activity.
Identifiants
pubmed: 33669408
pii: ijms22041956
doi: 10.3390/ijms22041956
pmc: PMC7920434
pii:
doi:
Substances chimiques
BCL2L1 protein, human
0
bcl-X Protein
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Curr Pharm Des. 2014;20(2):223-44
pubmed: 23701547
Nat Rev Microbiol. 2015 Aug;13(8):471-83
pubmed: 26179359
Transfus Med Hemother. 2016 May;43(3):203-22
pubmed: 27403093
Adv Exp Med Biol. 2012;942:157-83
pubmed: 22399422
Biochem J. 2005 Nov 15;392(Pt 1):135-43
pubmed: 16048439
mBio. 2014 Mar 04;5(2):e00031-14
pubmed: 24595369
Arch Public Health. 2017 Mar 27;75:15
pubmed: 28352464
Avian Dis. 2020 Jun;64(2):109-122
pubmed: 32550610
J Immunol. 1981 Jul;127(1):272-8
pubmed: 6263973
Viruses. 2017 Dec 21;10(1):
pubmed: 29267225
Front Microbiol. 2019 Dec 05;10:2828
pubmed: 31866988
Cell Death Differ. 2017 Apr;24(4):660-671
pubmed: 28186502
Arch Dermatol Res. 2000 May;292(5):225-32
pubmed: 10867810
Mol Ther. 2010 Aug;18(8):1440-9
pubmed: 20551913
Viruses. 2017 Apr 10;9(4):
pubmed: 28394272
EMBO J. 2003 Apr 1;22(7):1707-15
pubmed: 12660176
Nat Rev Neurol. 2016 Apr;12(4):234-48
pubmed: 26965674
Front Biosci. 2006 Sep 01;11:2672-713
pubmed: 16720343
Nat Cell Biol. 2015 Oct;17(10):1270-81
pubmed: 26344567
Biochimie. 2002 Feb-Mar;84(2-3):131-41
pubmed: 12022944
Lancet. 2020 Mar 14;395(10227):854
pubmed: 32171396
Gynecol Oncol. 1998 Sep;70(3):398-403
pubmed: 9790794
Int Immunopharmacol. 2013 Aug;16(4):466-74
pubmed: 23669332
Cell Res. 2020 Oct;30(10):873-884
pubmed: 32620850
Front Immunol. 2019 Feb 19;10:262
pubmed: 30838001
Int J Oncol. 2015 Apr;46(4):1609-18
pubmed: 25625567
Mol Ther Oncolytics. 2015 Sep 23;2:15013
pubmed: 27119108
J Chromatogr A. 2016 Sep 23;1465:117-25
pubmed: 27578410
Science. 2017 Jul 14;357(6347):204-208
pubmed: 28706073
Int J Cancer. 2016 Jan 15;138(2):507-14
pubmed: 26260669
Viruses. 2010 Sep;2(9):2037-77
pubmed: 21994719
Blood. 2000 Jul 1;96(1):275-81
pubmed: 10891462
J Virol. 2019 Sep 12;93(19):
pubmed: 31315992
Oral Dis. 2020 May 31;:
pubmed: 32475006
Oncogene. 2004 Nov 11;23(53):8619-28
pubmed: 15361852
Emerg Microbes Infect. 2018 Jul 31;7(1):135
pubmed: 30061622
Nat Rev Immunol. 2020 Aug;20(8):471-482
pubmed: 32051540
Malays J Pathol. 2020 Apr;42(1):3-11
pubmed: 32342926
J Gastroenterol Hepatol. 2009 Mar;24(3):336-45
pubmed: 19335784
J Virol. 2018 Jun 29;92(14):
pubmed: 29743359
Exp Mol Med. 2015 Jan 23;47:e132
pubmed: 25613729
Adv Virus Res. 2017;99:39-60
pubmed: 29029729
Sci Rep. 2017 Jul 13;7(1):5352
pubmed: 28706209
Pathology. 2020 Jan;52(1):40-52
pubmed: 31706670
World J Hepatol. 2015 Mar 27;7(3):583-92
pubmed: 25848482
Adv Cancer Res. 2018;138:41-69
pubmed: 29551129
Oncolytic Virother. 2018 Nov 26;7:117-128
pubmed: 30538968
Cell Death Dis. 2013 Jul 25;4:e742
pubmed: 23887633
Bioinformation. 2019 Apr 15;15(4):299-306
pubmed: 31285648
Br J Pharmacol. 2014 Apr;171(8):1973-87
pubmed: 24117105
Gastroenterology. 2019 Jan;156(2):384-399
pubmed: 30268787
J Virol. 2002 Sep;76(18):9407-19
pubmed: 12186923
Int J Mol Sci. 2017 Nov 06;18(11):
pubmed: 29113144
Philos Trans R Soc Lond B Biol Sci. 2017 Oct 19;372(1732):
pubmed: 28893937
Leukemia. 2020 Mar;34(3):947-952
pubmed: 31636344
Front Oncol. 2018 Jun 13;8:211
pubmed: 29951372
Int J Cancer. 2017 Sep 15;141(6):1257-1264
pubmed: 28568891
Oncol Lett. 2018 May;15(5):7537-7544
pubmed: 29725459
Biochem J. 2015 May 1;467(3):495-505
pubmed: 25714678
J Vet Med Sci. 2019 Feb 9;81(2):204-212
pubmed: 30541984
J Biol Chem. 2012 Apr 27;287(18):15118-33
pubmed: 22403404
Blood Adv. 2020 Oct 13;4(19):4775-4787
pubmed: 33017468
Int J Mol Sci. 2015 Mar 05;16(3):5076-124
pubmed: 25751724
Genes Cells. 2017 Dec;22(12):993-1003
pubmed: 29193479
PLoS One. 2019 Sep 20;14(9):e0222943
pubmed: 31539406
Curr Top Microbiol Immunol. 2013;369:113-42
pubmed: 23463199
Curr Med Chem. 2003 Aug;10(16):1535-51
pubmed: 12871125
J Biol Chem. 2004 Dec 3;279(49):51688-96
pubmed: 15459189
Cold Spring Harb Perspect Med. 2016 Jan 04;6(1):a021360
pubmed: 26729756
Viruses. 2014 Mar 11;6(3):1149-87
pubmed: 24618856
AIDS Rev. 2009 Apr-Jun;11(2):91-102
pubmed: 19529749
Cell Prolif. 2019 Nov;52(6):e12703
pubmed: 31621133
Emerg Microbes Infect. 2016 Aug 03;5(8):e81
pubmed: 27485496
J Pathol. 2019 Jun;248(2):155-163
pubmed: 30680725
Br J Haematol. 2015 Apr;169(1):142-5
pubmed: 25776535
Breast Cancer Res Treat. 2004 Sep;87(1):33-44
pubmed: 15377849
J Virol. 2015 Mar;89(6):2990-4
pubmed: 25540375
Hepatobiliary Surg Nutr. 2015 Feb;4(1):1-10
pubmed: 25713800
Oncol Res. 2017 Jan 2;25(1):29-34
pubmed: 28081730
Cancers (Basel). 2018 May 29;10(6):
pubmed: 29843478
Hepatology. 2001 Jul;34(1):55-61
pubmed: 11431734
Acta Biomed. 2020 Mar 19;91(1):157-160
pubmed: 32191675
Int J Mol Sci. 2018 Nov 14;19(11):
pubmed: 30441796
Virus Res. 2019 Jan 2;259:90-96
pubmed: 30391399
Viruses. 2019 Nov 15;11(11):
pubmed: 31731618
Blood. 2011 May 5;117(18):4726-35
pubmed: 21385849
J Hepatol. 2016 Apr;64(1 Suppl):S4-S16
pubmed: 27084035
BMC Cancer. 2017 Aug 30;17(1):594
pubmed: 28854921
Oxid Med Cell Longev. 2019 Aug 19;2019:1409582
pubmed: 31531178
World J Hepatol. 2015 Nov 18;7(26):2676-80
pubmed: 26609344
Infect Agent Cancer. 2014 Oct 15;9(1):34
pubmed: 25364378
Clin Ophthalmol. 2018 Sep 07;12:1707-1711
pubmed: 30233134
Arch Toxicol. 2013 Jul;87(7):1157-80
pubmed: 23543009
Euro Surveill. 2017 Jul 27;22(30):
pubmed: 28797326
Cancer Immunol Res. 2017 Oct;5(10):847-859
pubmed: 28912369
Vet Microbiol. 2020 Jan;240:108542
pubmed: 31902499
Biochim Biophys Acta Bioenerg. 2021 Mar 1;1862(3):148357
pubmed: 33359307
Microb Pathog. 2018 Nov;124:346-355
pubmed: 30179714
Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12480-5
pubmed: 26396258
Blood. 1997 May 1;89(9):3199-204
pubmed: 9129023
Chem Phys Lipids. 2014 Apr;179:70-4
pubmed: 24333953
Nat Commun. 2017 Oct 24;8(1):1123
pubmed: 29066722
Ann N Y Acad Sci. 2010 Jul;1201:183-8
pubmed: 20649555
J Biol Chem. 2014 Jan 3;289(1):89-99
pubmed: 24265320
Cell Death Dis. 2017 Dec 13;8(12):3216
pubmed: 29238043
Int J Oncol. 2018 Oct;53(4):1681-1690
pubmed: 30066853
Methods Mol Biol. 2020;2058:285-293
pubmed: 31486046
Annu Rev Virol. 2016 Sep 29;3(1):429-451
pubmed: 27482896
Lancet Infect Dis. 2020 Sep;20(9):e238-e244
pubmed: 32628905
Nat Commun. 2019 Jul 19;10(1):3192
pubmed: 31324803
Cell Death Differ. 2018 Jan;25(1):46-55
pubmed: 29053143
J Immunol. 2004 Apr 1;172(7):4444-53
pubmed: 15034060
Endocrinology. 2006 Oct;147(10):4960-7
pubmed: 16794010
Viruses. 2017 Nov 16;9(11):
pubmed: 29144413
Brief Funct Genomics. 2018 Nov 26;17(6):402-414
pubmed: 29040388
Pathogens. 2019 May 11;8(2):
pubmed: 31083509
Oncoimmunology. 2018 Sep 19;8(1):e1512329
pubmed: 30546947
PLoS One. 2017 Dec 29;12(12):e0189730
pubmed: 29287068
Int J Mol Sci. 2019 Jan 29;20(3):
pubmed: 30700020
Biochim Biophys Acta. 2006 May-Jun;1757(5-6):639-47
pubmed: 16678785
J Virol. 2019 Feb 19;93(5):
pubmed: 30541833
J Virol. 2019 Jun 14;93(13):
pubmed: 30996092
Lancet. 2006 Aug 5;368(9534):489-504
pubmed: 16890836
Viruses. 2015 Dec 24;8(1):
pubmed: 26712781
PLoS Pathog. 2009 Feb;5(2):e1000291
pubmed: 19242562
F1000Res. 2020 Feb 26;9:
pubmed: 32148779
J Virol. 2015 Sep;89(17):8922-31
pubmed: 26085145
Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18471-6
pubmed: 23091012
Surgery. 2004 Jun;135(6):604-12
pubmed: 15179366