Intestinal Dysbiosis in Young Cystic Fibrosis Rabbits.
cystic fibrosis
feces microbiome
intestinal dysbiosis
rabbits
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
16 Feb 2021
16 Feb 2021
Historique:
received:
19
01
2021
revised:
03
02
2021
accepted:
11
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
Individuals with cystic fibrosis (CF) often experience gastrointestinal (GI) abnormalities. In recent years, the intestinal microbiome has been postulated as a contributor to the development of CF-associated GI complications, hence representing a potential therapeutic target for treatment. We recently developed a rabbit model of CF, which is shown to manifest many human patient-like pathological changes, including intestinal obstruction. Here, we investigated the feces microbiome in young CF rabbits in the absence of antibiotics treatment. Stool samples were collected from seven- to nine-week-old CF rabbits (
Identifiants
pubmed: 33669429
pii: jpm11020132
doi: 10.3390/jpm11020132
pmc: PMC7920415
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL133162
Pays : United States
Organisme : NIH HHS
ID : HL133162
Pays : United States
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