Crosstalk between Different DNA Repair Pathways Contributes to Neurodegenerative Diseases.
ALS
Alzheimer
DNA damage response
PARP
Parkinson
cGAS-STING
neurodegeneration
neuroinflammation
oxidative stress
Journal
Biology
ISSN: 2079-7737
Titre abrégé: Biology (Basel)
Pays: Switzerland
ID NLM: 101587988
Informations de publication
Date de publication:
19 Feb 2021
19 Feb 2021
Historique:
received:
31
01
2021
revised:
11
02
2021
accepted:
16
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
Genomic integrity is maintained by DNA repair and the DNA damage response (DDR). Defects in certain DNA repair genes give rise to many rare progressive neurodegenerative diseases (NDDs), such as ocular motor ataxia, Huntington disease (HD), and spinocerebellar ataxias (SCA). Dysregulation or dysfunction of DDR is also proposed to contribute to more common NDDs, such as Parkinson's disease (PD), Alzheimer's disease (AD), and Amyotrophic Lateral Sclerosis (ALS). Here, we present mechanisms that link DDR with neurodegeneration in rare NDDs caused by defects in the DDR and discuss the relevance for more common age-related neurodegenerative diseases. Moreover, we highlight recent insight into the crosstalk between the DDR and other cellular processes known to be disturbed during NDDs. We compare the strengths and limitations of established model systems to model human NDDs, ranging from
Identifiants
pubmed: 33669593
pii: biology10020163
doi: 10.3390/biology10020163
pmc: PMC7922961
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Helse Sør-Øst RHF
ID : 279922
Organisme : Norges Forskningsråd
ID : 302483
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