Statins Directly Influence the Polarization of Adipose Tissue Macrophages: A Role in Chronic Inflammation.
human
hypercholesterolemia
inflammation
macrophage polarization
statins
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
19 Feb 2021
19 Feb 2021
Historique:
received:
29
12
2020
revised:
07
02
2021
accepted:
17
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
Statins represent one of the most widely used classes of drugs in current medicine. In addition to a substantial decrease in atherogenic low density lipoprotein (LDL) particle concentrations, several large trials have documented their potent anti-inflammatory activity. Based on our preliminary data, we showed that statins are able to decrease the proportion of pro-inflammatory macrophages (CD14+16+CD36high) in visceral adipose tissue in humans. In the present study including 118 healthy individuals (living kidney donors), a very close relationship between the pro-inflammatory macrophage proportion and LDL cholesterol levels was found. This was confirmed after adjustment for the most important risk factors. The effect of statins on the proportion of pro-inflammatory macrophages was also confirmed in an experimental model of the Prague hereditary hypercholesterolemia rat. A direct anti-inflammatory effect of fluvastatin on human macrophage polarization in vitro was documented. Based on modifying the LDL cholesterol concentrations, statins are suggested to decrease the cholesterol inflow through the lipid raft of macrophages in adipose tissue and hypercholesterolemia to enhance the pro-inflammatory macrophage phenotype polarization. On the contrary, due to their opposite effect, statins respond with anti-inflammatory activity, affecting the whole organism.
Identifiants
pubmed: 33669779
pii: biomedicines9020211
doi: 10.3390/biomedicines9020211
pmc: PMC7923086
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministerstvo Zdravotnictví Ceské Republiky
ID : 17-28103A
Références
N Engl J Med. 2007 Jun 7;356(23):2388-98
pubmed: 17554120
J Am Coll Cardiol. 2014 Dec 2;64(21):2207-17
pubmed: 25456755
Vascul Pharmacol. 2018 Nov;110:49-54
pubmed: 30098417
J Vis Exp. 2016 Oct 18;(116):
pubmed: 27805599
Clin Chem. 2008 Feb;54(2):234-7
pubmed: 18223130
Nat Immunol. 2010 Feb;11(2):136-40
pubmed: 20023662
Curr Atheroscler Rep. 2018 Feb 14;20(3):12
pubmed: 29445885
Haematologica. 2013 Jan;98(1):31-40
pubmed: 22801964
Nutrients. 2019 Dec 18;12(1):
pubmed: 31861434
Cell. 1992 Feb 21;68(4):673-82
pubmed: 1739974
Eur J Prev Cardiol. 2018 Feb;25(3):328-334
pubmed: 29154680
Eur Heart J. 2020 Jun 21;41(24):2313-2330
pubmed: 32052833
Annu Rev Pharmacol Toxicol. 2005;45:89-118
pubmed: 15822172
Circ Res. 2005 May 13;96(9):939-49
pubmed: 15890981
Nat Chem Biol. 2017 Mar;13(3):268-274
pubmed: 28024150
Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2292-301
pubmed: 17673705
Am J Cardiol. 2010 Jul 15;106(2):204-9
pubmed: 20599004
Crit Care. 2012 Dec 11;16(6):R231
pubmed: 23232151
Neuropharmacology. 2018 Jan;128:244-254
pubmed: 29054366
Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2590-2600
pubmed: 30354246
JAMA. 2001 Jul 4;286(1):64-70
pubmed: 11434828
N Engl J Med. 1996 Oct 3;335(14):1001-9
pubmed: 8801446
Immunology. 2018 May;154(1):69-75
pubmed: 29392731
J Lipid Res. 2016 Oct;57(10):1899-1905
pubmed: 27481939
Nat Immunol. 2011 May;12(5):408-15
pubmed: 21478880
Physiol Res. 2009;58 Suppl 2:S95-S100
pubmed: 20131941
Lancet. 2009 Apr 4;373(9670):1175-82
pubmed: 19329177
Atherosclerosis. 2012 Apr;221(2):303-10
pubmed: 22071358
Eur Heart J. 2009 May;30(9):1046-56
pubmed: 19141562
Arterioscler Thromb Vasc Biol. 2012 Sep;32(9):e117-25
pubmed: 22772753
Rheumatology (Oxford). 2009 Mar;48(3):233-42
pubmed: 19151033
J Clin Invest. 2011 Oct;121(10):4138-49
pubmed: 21968112
Eur J Biochem. 2004 May;271(10):2028-36
pubmed: 15128312
N Engl J Med. 2005 Jan 6;352(1):20-8
pubmed: 15635109
N Engl J Med. 1995 Sep 7;333(10):621-7
pubmed: 7637722
Nature. 2011 May 19;473(7347):317-25
pubmed: 21593864
J Transl Med. 2016 Jul 11;14(1):208
pubmed: 27400732
Cell Physiol Biochem. 2015;37(2):419-431
pubmed: 26314949
J Neuroinflammation. 2017 Aug 23;14(1):167
pubmed: 28835272
Br J Pharmacol. 2016 Feb;173(4):741-51
pubmed: 26332942
Circulation. 1984 Sep;70(3):331-6
pubmed: 6744536
Arterioscler Thromb Vasc Biol. 2008 May;28(5):871-7
pubmed: 18323514
N Engl J Med. 2002 Nov 14;347(20):1557-65
pubmed: 12432042
J Lipid Res. 2020 Dec;61(12):1577-1588
pubmed: 32907987
J Int Med Res. 2018 Aug;46(8):3365-3373
pubmed: 30058421