Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva.
ALK2
BMP
FOP
TGF-β
activin
bone
repurposed drug
signal transduction
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
19 Feb 2021
19 Feb 2021
Historique:
received:
11
01
2021
revised:
08
02
2021
accepted:
15
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
Fibrodysplasia ossificans progressiva (FOP) is an ultrarare congenital disease that progresses through intermittent episodes of bone formation at ectopic sites. FOP patients carry heterozygous gene point mutations in activin A receptor type I
Identifiants
pubmed: 33669809
pii: biomedicines9020213
doi: 10.3390/biomedicines9020213
pmc: PMC7922784
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Ministerio de Ciencia e Innovación
ID : BFU2017-82421-P
Organisme : Wellcome
ID : 106169/ZZ14/Z
Organisme : FOP Friends and Innovative Medicines Initiative 2 Joint Undertaking
ID : STOPFOP grant number 821600
Organisme : AFM-Telethon
ID : 22379
Organisme : FOP Italia
ID : Grant Italia 2020
Organisme : Fundacio la Marato de TV3
ID : 202038
Organisme : Netherlands Cardiovascular Research Initiative the Dutch Heart Foundation
ID : PHAEDRA-IMPACT
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