Single Molecule Characterization of Amyloid Oligomers.
amyloid oligomers
neurodegenerative disease
protein aggregation
single molecule fluorescence detection
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
11 Feb 2021
11 Feb 2021
Historique:
received:
30
12
2020
revised:
29
01
2021
accepted:
02
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
10
4
2021
Statut:
epublish
Résumé
The misfolding and aggregation of polypeptide chains into β-sheet-rich amyloid fibrils is associated with a wide range of neurodegenerative diseases. Growing evidence indicates that the oligomeric intermediates populated in the early stages of amyloid formation rather than the mature fibrils are responsible for the cytotoxicity and pathology and are potentially therapeutic targets. However, due to the low-populated, transient, and heterogeneous nature of amyloid oligomers, they are hard to characterize by conventional bulk methods. The development of single molecule approaches provides a powerful toolkit for investigating these oligomeric intermediates as well as the complex process of amyloid aggregation at molecular resolution. In this review, we present an overview of recent progress in characterizing the oligomerization of amyloid proteins by single molecule fluorescence techniques, including single-molecule Förster resonance energy transfer (smFRET), fluorescence correlation spectroscopy (FCS), single-molecule photobleaching and super-resolution optical imaging. We discuss how these techniques have been applied to investigate the different aspects of amyloid oligomers and facilitate understanding of the mechanism of amyloid aggregation.
Identifiants
pubmed: 33670093
pii: molecules26040948
doi: 10.3390/molecules26040948
pmc: PMC7916856
pii:
doi:
Substances chimiques
Amyloid
0
Amyloid beta-Peptides
0
Amyloidogenic Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 21673278
Organisme : National Natural Science Foundation of China
ID : 31920103011
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