Extracellular Vesicles: Emerging Modulators of Cancer Drug Resistance.
MDR transporters
cancer drug resistance
cancer stem cells
chemotherapy
extracellular vesicles
miRNAs
tumor microenvironment
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
11 Feb 2021
11 Feb 2021
Historique:
received:
13
01
2021
revised:
03
02
2021
accepted:
08
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
Extracellular vesicles (EVs) have recently emerged as crucial modulators of cancer drug resistance. Indeed, it has been shown that they can directly sequester anti-tumor drugs, decreasing their effective concentration at target sites. Moreover, they facilitate the horizontal transfer of specific bioactive cargoes able to regulate proliferative, apoptotic, and stemness programs in recipient cells, potentially conferring a resistant phenotype to drug-sensitive cancer cells. Finally, EVs can mediate the communication between the tumor and both stromal and immune cells within the microenvironment, promoting treatment escape. In this context, clarifying the EV-driven resistance mechanisms might improve not only tumor diagnosis and prognosis but also therapeutic outcomes. Detailed cellular and molecular events occurring during the development of EV-mediated cancer drug resistance are described in this review article.
Identifiants
pubmed: 33670185
pii: cancers13040749
doi: 10.3390/cancers13040749
pmc: PMC7916933
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P006205/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : A28052
Pays : United Kingdom
Organisme : AIRC
ID : Fellowship For Italy
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