Serum microRNA Levels in Diabetes Mellitus.
diabetes mellitus
diabetic retinopathy
serum microRNA
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
11 Feb 2021
11 Feb 2021
Historique:
received:
20
12
2020
revised:
29
01
2021
accepted:
06
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
The aim of our study is to evaluate the serum circulating levels of some miRNA, such as hsa-let-7b-5p, hsa-let-7a-5p, hsa-miR-320b, hsa-miR-23a-3p, hsa-miR-27a-3p, hsa-miR-15a-5p, and hsa-miR-495-3, in diabetic patients without diabetic retinopathy (DR), diabetic patients with DR, and, healthy subjects in order to find reliable and reproducible biomarkers for DR. A total of 45 subjects underwent serum sampling for miRNAs evaluation and a complete ophthalmologic examination, including microperimetry and widefield swept source optical coherence tomography angiography (OCTA). Total circulating RNA was isolated from patients using the miRNeasy Serum/Plasma Kit. Serum miRNA expression levels were significantly different in the three groups. In detail, circulating hsa-miR-15a-5p levels were significantly reduced in both diabetic patients without DR and diabetic patients with DR (
Identifiants
pubmed: 33670401
pii: diagnostics11020284
doi: 10.3390/diagnostics11020284
pmc: PMC7918507
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Int Ophthalmol. 1989 Jul;13(4):269-79
pubmed: 2482264
Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13944-9
pubmed: 16166262
Mol Cell Biol. 2017 Jul 28;37(16):
pubmed: 28584193
World J Gastroenterol. 2019 Nov 14;25(42):6322-6341
pubmed: 31754293
IUBMB Life. 2019 Mar;71(3):310-320
pubmed: 30468285
Clin Chim Acta. 2020 Feb;501:147-153
pubmed: 31678272
Neural Regen Res. 2017 Apr;12(4):580-581
pubmed: 28553335
Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3044-51
pubmed: 16799051
Acta Diabetol. 2014 Oct;51(5):823-31
pubmed: 24981880
JAMA Ophthalmol. 2018 Aug 1;136(8):929-936
pubmed: 29902297
Ophthalmology. 2017 Jul;124(7):944-952
pubmed: 28318637
ISRN Endocrinol. 2012;2012:549875
pubmed: 22900199
Ophthalmic Res. 2019;62(4):211-217
pubmed: 31129667
Antioxid Redox Signal. 2017 Nov 1;27(13):913-930
pubmed: 28173719
Cell Physiol Biochem. 2016;38(5):2063-78
pubmed: 27165190
Retina. 2010 Jun;30(6):908-16
pubmed: 20168272
Acta Ophthalmol. 2017 Dec;95(8):e751-e755
pubmed: 28211261
J Immunol Res. 2018 Jun 7;2018:7510174
pubmed: 29977932
Int J Mol Sci. 2017 Feb 28;18(3):
pubmed: 28264477
Invest Ophthalmol Vis Sci. 2017 May 1;58(6):BIO307-BIO315
pubmed: 29059262
Arch Ophthalmol. 1998 May;116(5):589-97
pubmed: 9596494
Eur Rev Med Pharmacol Sci. 2019 Sep;23(18):7749-7756
pubmed: 31599400
J Optom. 2019 Jul - Sep;12(3):174-179
pubmed: 29843983
Diabet Med. 2019 Apr;36(4):424-433
pubmed: 30474144
Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):190-196
pubmed: 28114579
Clin Exp Pharmacol Physiol. 2009 Feb;36(2):181-8
pubmed: 18986336
Prog Retin Eye Res. 2014 Nov;43:92-107
pubmed: 25128741
Acta Diabetol. 2019 Dec;56(12):1293-1303
pubmed: 31468199
Quant Imaging Med Surg. 2018 Sep;8(8):743-753
pubmed: 30306055
Eye Vis (Lond). 2019 Nov 18;6:37
pubmed: 31832448
Ophthalmology. 2017 Feb;124(2):235-244
pubmed: 27887743
Theranostics. 2018 Jun 23;8(14):3874-3890
pubmed: 30083267
Nat Rev Genet. 2008 Feb;9(2):102-14
pubmed: 18197166
Nat Rev Mol Cell Biol. 2010 Apr;11(4):252-63
pubmed: 20216554
Invest Ophthalmol Vis Sci. 2020 Mar 9;61(3):50
pubmed: 32232345
Neural Regen Res. 2019 Nov;14(11):1858-1869
pubmed: 31290435
J Biophotonics. 2017 Nov;10(11):1464-1472
pubmed: 28493437
Biomedicines. 2018 Mar 30;6(2):
pubmed: 29601548
Graefes Arch Clin Exp Ophthalmol. 2018 Jul;256(7):1275-1280
pubmed: 29713816
Biomed Pharmacother. 2018 Oct;106:923-929
pubmed: 30119264
Hum Mol Genet. 2018 May 15;27(10):1763-1771
pubmed: 29528396
Acta Diabetol. 2017 Jul;54(7):695-702
pubmed: 28474119
Acta Diabetol. 2018 May;55(5):469-477
pubmed: 29453673
Int J Mol Sci. 2019 Dec 17;20(24):
pubmed: 31861156
Oxid Med Cell Longev. 2019 Dec 13;2019:9567641
pubmed: 31915515
Lancet. 2010 Jul 10;376(9735):124-36
pubmed: 20580421
Cardiovasc Pathol. 2015 Jul-Aug;24(4):199-206
pubmed: 25958013