Apoptotic Blocks in Primary Non-Hodgkin B Cell Lymphomas Identified by BH3 Profiling.

BCL2 BH3 profiling DLBCL MCL1 NHL apoptosis venetoclax

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
28 Feb 2021
Historique:
received: 02 02 2021
revised: 17 02 2021
accepted: 23 02 2021
entrez: 6 3 2021
pubmed: 7 3 2021
medline: 7 3 2021
Statut: epublish

Résumé

To determine causes of apoptotic resistance, we analyzed 124 primary B cell NHL samples using BH3 profiling, a technique that measures the mitochondrial permeabilization upon exposure to synthetic BH3 peptides. Our cohort included samples from chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), high-grade B cell lymphoma with translocations in

Identifiants

pubmed: 33670870
pii: cancers13051002
doi: 10.3390/cancers13051002
pmc: PMC7957722
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : CIHR
ID : 299607
Pays : Canada

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Auteurs

Ryan N Rys (RN)

Department of Physiology, McGill University, Montreal, QC H3G 1Y6, Canada.
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T 1E2, Canada.

Claudia M Wever (CM)

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T 1E2, Canada.
Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada.

Dominique Geoffrion (D)

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T 1E2, Canada.
Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada.
Department of Experimental Surgery, McGill University, Montreal, QC H3G 1A4, Canada.

Christophe Goncalves (C)

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T 1E2, Canada.

Artin Ghassemian (A)

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T 1E2, Canada.
Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada.

Eugene Brailovski (E)

Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada.

Jeremy Ryan (J)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Liliana Stoica (L)

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T 1E2, Canada.

Josée Hébert (J)

Department of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada.
Division of Hematology-Oncology and Quebec Leukemia Cell Bank, Maisonneuve Rosemont Hospital, Montreal, QC H1T 2M4, Canada.

Tina Petrogiannis-Haliotis (T)

Division of Pathology, Jewish General Hospital, Montréal, QC H3T 1E2, Canada.

Svetlana Dmitrienko (S)

Division of Pathology, Jewish General Hospital, Montréal, QC H3T 1E2, Canada.

Saul Frenkiel (S)

Department of Otolaryngology-Head and Neck Surgery, Jewish General Hospital, Montreal, QC H3T 1E2, Canada.

Annette Staiger (A)

Department of Pathology, Robert-Bosch Hospital, 70184 Stuttgart, Germany.
Dr. Margarete-Fischer-Bosch-Institute of Clinical Pharmacology, University of Tübingen, 70376 Stuttgart, Germany.

German Ott (G)

Department of Pathology, Robert-Bosch Hospital, 70184 Stuttgart, Germany.

Christian Steidl (C)

Center for Lymphoid Cancer, BC Cancer, Vancouver, BC V5Z 1L3, Canada.

David W Scott (DW)

Center for Lymphoid Cancer, BC Cancer, Vancouver, BC V5Z 1L3, Canada.

Pierre Sesques (P)

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T 1E2, Canada.

Sonia Del Rincon (S)

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T 1E2, Canada.
Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada.

Koren K Mann (KK)

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T 1E2, Canada.
Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada.

Anthony Letai (A)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Nathalie A Johnson (NA)

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC H3T 1E2, Canada.
Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada.
Departments of Medicine and Oncology, Jewish General Hospital, Montreal, QC H3T 1E2, Canada.

Classifications MeSH