Fibrotic Phenotype of Peritumour Mesenteric Adipose Tissue in Human Colon Cancer: A Potential Hallmark of Metastatic Properties.
Adipose Tissue
/ metabolism
Aged
Aged, 80 and over
Collagen Type I
/ genetics
Collagen Type I, alpha 1 Chain
Colonic Neoplasms
/ physiopathology
Extracellular Matrix
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Male
Mesentery
Middle Aged
Tumor Microenvironment
/ genetics
Wnt Signaling Pathway
adipose tissue
colon cancer
extracellular matrix
tumour microenvironment
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Feb 2021
28 Feb 2021
Historique:
received:
19
01
2021
revised:
14
02
2021
accepted:
22
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
1
5
2021
Statut:
epublish
Résumé
The impact of tumour associated stroma on cancer metastasis is an emerging field. However, cancer associated genes in peritumoral adipose tissue (pAT) in human colon cancer have not been explored. The aim of this study was to identify differentially expressed genes (DEGs) associated with cancer pathways in mesenteric pAT compared with adjacent adipose tissue. In total, nine patients with colon cancer pathological stage T2/T4 were employed in this study. DEGs were identified in 6 patients employing Nanostring PanCancer Pathway Panel and pathway enrichment analyses were performed. Differential expression of the 5 most up-regulated and 2 down regulated genes was validated with qRT-PCR. Results showed collagen type I alpha 1 chain (
Identifiants
pubmed: 33670920
pii: ijms22052430
doi: 10.3390/ijms22052430
pmc: PMC7957668
pii:
doi:
Substances chimiques
COL1A1 protein, human
0
Collagen Type I
0
Collagen Type I, alpha 1 Chain
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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