Time and Mode of Epidemic HCV-2 Subtypes Spreading in Europe: Phylodynamics in Italy and Albania.
HCV-2 Re estimation
HCV-2 subtypes
epidemiological history of HCV-2
evolutionary demography of HCV-2
phylodynamics of HCV-2 in Italy and Albania
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
17 Feb 2021
17 Feb 2021
Historique:
received:
21
01
2021
revised:
12
02
2021
accepted:
14
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
Hepatitis C virus (HCV) genotype 2 causes about 10% of global infections and has the most variable circulation profile in Europe. The history of "endemic" HCV-2 subtypes has been satisfactorily reconstructed, instead there is little information about the recent spread of the "epidemic" subtypes, including HCV-2c. To investigate the origin and dispersion pathways of HCV-2c, 245 newly characterized Italian and Albanian HCV-2 NS5B sequences were aligned with 247 publicly available sequences and included in phylogeographic and phylodynamic analyses using the Bayesian framework. Our findings show that HCV-2c was the most prevalent subtype in Italy and Albania. The phylogeographic analysis suggested an African origin of HCV-2c before it reached Italy about in the 1940s. Phylodynamic analysis revealed an exponential increase in the effective number of infections and Re in Italy between the 1940s and 1960s, and in Albania between the 1990s and the early 2000s. It seems very likely that HCV-2c reached Italy from Africa at the time of the second Italian colonization but did not reach Albania until the period of dramatic migration to Italy in the 1990s. This study contributes to reconstructing the history of the spread of epidemic HCV-2 subtypes to Europe.
Identifiants
pubmed: 33671355
pii: diagnostics11020327
doi: 10.3390/diagnostics11020327
pmc: PMC7922790
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
J Gen Virol. 2015 Aug;96(8):2157-2164
pubmed: 25888623
Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6815-9
pubmed: 9192648
Viruses. 2015 Jul 17;7(7):3974-94
pubmed: 26193306
Anticancer Res. 2007 Mar-Apr;27(2):1219-22
pubmed: 17465266
Mol Biol Evol. 2004 Jun;21(6):1074-80
pubmed: 15014142
Hepatology. 2015 Jan;61(1):77-87
pubmed: 25069599
Am Nat. 2013 Oct;182(4):494-513
pubmed: 24021402
J Gen Virol. 2004 Nov;85(Pt 11):3173-3188
pubmed: 15483230
PLoS Pathog. 2012;8(5):e1002720
pubmed: 22615575
J Hepatol. 2017 Aug;67(2):224-236
pubmed: 28343981
Lancet. 2000 Nov 4;356(9241):1572-3
pubmed: 11075774
PLoS Curr. 2009 Sep 02;1:RRN1031
pubmed: 20029613
Int J Infect Dis. 2014 Jan;18:90-3
pubmed: 24169401
Diagn Microbiol Infect Dis. 2002 Mar;42(3):169-73
pubmed: 11929687
PLoS One. 2008 Feb 20;3(2):e1615
pubmed: 18286172
Hepatology. 1997 Oct;26(4):1006-11
pubmed: 9328327
PLoS One. 2017 Jun 1;12(6):e0179064
pubmed: 28570623
J Hepatol. 2008 Jan;48(1):148-62
pubmed: 18022726
Science. 2001 Jun 22;292(5525):2323-5
pubmed: 11423661
Hepatology. 2014 Jan;59(1):318-27
pubmed: 24115039
Lancet. 1995 May 13;345(8959):1211-3
pubmed: 7739308
J Virol Methods. 2005 Jun;126(1-2):139-48
pubmed: 15847930
Trials. 2014 May 07;15:159
pubmed: 24886378
J Mol Evol. 2002 Jan;54(1):62-70
pubmed: 11734899
Bioinformatics. 2002 Mar;18(3):502-4
pubmed: 11934758
J Med Virol. 2008 Oct;80(10):1732-9
pubmed: 18712846
Mol Biol Evol. 2012 Aug;29(8):1969-73
pubmed: 22367748
J Viral Hepat. 1995;2(1):33-8
pubmed: 7493292
Mol Biol Evol. 2016 Aug;33(8):2167-9
pubmed: 27189542
Infect Genet Evol. 2014 Aug;26:352-8
pubmed: 24973737
Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13253-8
pubmed: 10557307
J Med Virol. 2002 Nov;68(3):352-6
pubmed: 12226821
Mol Biol Evol. 2001 Jun;18(6):1001-13
pubmed: 11371589
Eur J Gastroenterol Hepatol. 2010 Feb;22(2):167-71
pubmed: 19734797
J Virol. 2012 Jul;86(14):7677-87
pubmed: 22573865
J Clin Microbiol. 1994 Jan;32(1):232-4
pubmed: 8126188
Hepatology. 2004 May;39(5):1455; author reply 1455-6
pubmed: 15122778
J Gen Virol. 2009 Sep;90(Pt 9):2086-96
pubmed: 19474244
Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):228-33
pubmed: 23248286
J Clin Lab Anal. 2019 Jun;33(5):e22876
pubmed: 30843304
J Med Virol. 2007 Jan;79(1):26-34
pubmed: 17133555
BMC Evol Biol. 2011 May 19;11:131
pubmed: 21595904
J Med Virol. 2005 Jul;76(3):327-32
pubmed: 15902713
Infect Genet Evol. 2005 Mar;5(2):131-9
pubmed: 15639745
Virus Evol. 2015 Oct 02;1(1):vev013
pubmed: 27774285
Int J Parasitol. 2007 Jul;37(8-9):839-49
pubmed: 17521655
Infect Genet Evol. 2013 Jul;17:223-30
pubmed: 23603418
Nucleic Acids Res. 1994 Nov 11;22(22):4673-80
pubmed: 7984417
J Hepatol. 1998 Nov;29(5):701-6
pubmed: 9833906