Metabolic Diseases and Down Syndrome: How Are They Linked Together?
central regulation food intake
diabetes
down syndrome
endocrine disorders
immune system
inflammation
obesity
thyroid dysfunction
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
22 Feb 2021
22 Feb 2021
Historique:
received:
16
01
2021
revised:
15
02
2021
accepted:
17
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
Down syndrome is a genetic disorder caused by the presence of a third copy of chromosome 21, associated with intellectual disabilities. Down syndrome is associated with anomalies of both the nervous and endocrine systems. Over the past decades, dramatic advances in Down syndrome research and treatment have helped to extend the life expectancy of these patients. Improved life expectancy is obviously a positive outcome, but it is accompanied with the need to address previously overlooked complications and comorbidities of Down syndrome, including obesity and diabetes, in order to improve the quality of life of Down syndrome patients. In this focused review, we describe the associations between Down syndrome and comorbidities, obesity and diabetes, and we discuss the understanding of proposed mechanisms for the association of Down syndrome with metabolic disorders. Drawing molecular mechanisms through which Type 1 diabetes and Type 2 diabetes could be linked to Down syndrome could allow identification of novel drug targets and provide therapeutic solutions to limit the development of metabolic and cognitive disorders.
Identifiants
pubmed: 33671490
pii: biomedicines9020221
doi: 10.3390/biomedicines9020221
pmc: PMC7926648
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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