Genetically Raised Circulating Bilirubin Levels and Risk of Ten Cancers: A Mendelian Randomization Study.
Mendelian randomization
UGT1A1
bilirubin
cancer risk
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
15 02 2021
15 02 2021
Historique:
received:
07
01
2021
revised:
04
02
2021
accepted:
05
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
16
10
2021
Statut:
epublish
Résumé
Bilirubin, an endogenous antioxidant, may play a protective role in cancer development. We applied two-sample Mendelian randomization to investigate whether genetically raised bilirubin levels are causally associated with the risk of ten cancers (pancreas, kidney, endometrium, ovary, breast, prostate, lung, Hodgkin's lymphoma, melanoma, and neuroblastoma). The number of cases and their matched controls of European descent ranged from 122,977 and 105,974 for breast cancer to 1200 and 6417 for Hodgkin's lymphoma, respectively. A total of 115 single-nucleotide polymorphisms (SNPs) associated (
Identifiants
pubmed: 33671849
pii: cells10020394
doi: 10.3390/cells10020394
pmc: PMC7918902
pii:
doi:
Substances chimiques
Biomarkers
0
Bilirubin
RFM9X3LJ49
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MC_UU_12014/3
Pays : United Kingdom
Organisme : Austrian Science Fund FWF
ID : P 29608
Pays : Austria
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