FDG-PET Radiomics for Response Monitoring in Non-Small-Cell Lung Cancer Treated with Radiation Therapy.
FDG monitoring and retrospectively gated 4D PET/CT
PET radiomics
lung cancer
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
15 Feb 2021
15 Feb 2021
Historique:
received:
16
12
2020
revised:
05
02
2021
accepted:
07
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
The aim of this study is to identify clinically relevant image feature (IF) changes during chemoradiation and evaluate their efficacy in predicting treatment response. Patients with non-small-cell lung cancer (NSCLC) were enrolled in two prospective trials (STRIPE, PET-Plan). We evaluated 48 patients who underwent static (3D) and retrospectively-respiratory-gated 4D PET/CT scans before treatment and a 3D scan during or after treatment. Our proposed method rejects IF changes due to intrinsic variability. The IF variability observed across 4D PET is employed as a patient individualized normalization factor to emphasize statistically relevant IF changes during treatment. Predictions of overall survival (OS), local recurrence (LR) and distant metastasis (DM) were evaluated. From 135 IFs, only 17 satisfied the required criteria of being normally distributed across 4D PET and robust between 3D and 4D images. Changes during treatment in the area-under-the-curve of the cumulative standard-uptake-value histogram (δ
Identifiants
pubmed: 33672052
pii: cancers13040814
doi: 10.3390/cancers13040814
pmc: PMC7919471
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Conselleria de Sanitat Universal i Salut Pública from the Comunitat Valenciana
ID : PlanGenT
Organisme : European Comission
ID : 2019
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