Medicinal Use of Testosterone and Related Steroids Revisited.
aging
androgen receptor
antiandrogens
longevity
medicinal natural products
performance-enhancing drugs
selective androgen receptor modulators
testosterone
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
15 Feb 2021
15 Feb 2021
Historique:
received:
28
01
2021
revised:
11
02
2021
accepted:
11
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
10
4
2021
Statut:
epublish
Résumé
Testosterone derivatives and related compounds (such as anabolic-androgenic steroids-AAS) are frequently misused by athletes (both professional and amateur) wishing to promote muscle development and strength or to cover AAS misuse. Even though these agents are vastly regarded as abusive material, they have important pharmacological activities that cannot be easily replaced by other drugs and have therapeutic potential in a range of conditions (e.g., wasting syndromes, severe burns, muscle and bone injuries, anemia, hereditary angioedema). Testosterone and related steroids have been in some countries treated as controlled substances, which may affect the availability of these agents for patients who need them for therapeutic reasons in a given country. Although these agents are currently regarded as rather older generation drugs and their use may lead to serious side-effects, they still have medicinal value as androgenic, anabolic, and even anti-androgenic agents. This review summarizes and revisits the medicinal use of compounds based on the structure and biological activity of testosterone, with examples of specific compounds. Additionally, some of the newer androgenic-anabolic compounds are discussed such as selective androgen receptor modulators, the efficacy/adverse-effect profiles of which have not been sufficiently established and which may pose a greater risk than conventional androgenic-anabolic agents.
Identifiants
pubmed: 33672087
pii: molecules26041032
doi: 10.3390/molecules26041032
pmc: PMC7919692
pii:
doi:
Substances chimiques
Designer Drugs
0
Prodrugs
0
Steroids
0
Testosterone
3XMK78S47O
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Regional Development Fund - Project
ID : No. CZ.02.1.01/0.0/0.0/16_019/0000845
Organisme : The Institutional Plan of the UCT Prague
ID : A1_FPBT_2020_004
Références
S Afr Med J. 1975 Nov 15;49(49):2036-40
pubmed: 1242823
ACS Med Chem Lett. 2010 Dec 02;2(2):124-9
pubmed: 24900290
Rapid Commun Mass Spectrom. 2004;18(12):1245-049
pubmed: 15174177
Z Gesamte Inn Med. 1980 Nov 15;35(22):809-12
pubmed: 7467606
J Med Chem. 2009 Jun 25;52(12):3597-617
pubmed: 19432422
Drug Test Anal. 2019 Nov;11(11-12):1644-1655
pubmed: 31733090
Steroids. 1999 Jul;64(7):439-45
pubmed: 10443899
Metabolism. 1983 Jun;32(6):571-80
pubmed: 6341772
Expert Opin Emerg Drugs. 2012 Jun;17(2):239-59
pubmed: 22612692
Med Sci Sports Exerc. 2006 Aug;38(8):1451-61
pubmed: 16888459
Am J Gastroenterol. 2006 Nov;101(11):2659-62
pubmed: 16952289
Br J Clin Pharmacol. 2016 Jun;81(6):1091-102
pubmed: 26804967
Med Sci Sports Exerc. 2006 Apr;38(4):644-51
pubmed: 16679978
J Am Med Assoc. 1952 Apr 5;148(14):1212-6
pubmed: 14907362
J Pharmacol Exp Ther. 2005 Feb;312(2):546-53
pubmed: 15347734
Curr Neuropharmacol. 2015 Jan;13(1):89-100
pubmed: 26074745
J Clin Endocrinol Metab. 2001 Nov;86(11):5108-17
pubmed: 11701661
J Biol Chem. 2010 May 28;285(22):17054-64
pubmed: 20356837
Toxicol Sci. 2012 Apr;126(2):353-61
pubmed: 22273746
Am J Med. 1959 Feb;26(2):238-42
pubmed: 13617280
J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):87-95
pubmed: 22459616
J Hum Kinet. 2014 Jul 08;41:99-105
pubmed: 25114736
Exp Clin Endocrinol. 1994;102(1):1-32
pubmed: 8005205
J Med Chem. 1999 Jan 28;42(2):210-2
pubmed: 9925725
J Pediatr. 1992 Jul;121(1):49-55
pubmed: 1625092
Biol Pharm Bull. 2003 Nov;26(11):1563-9
pubmed: 14600402
Environ Health Perspect. 2001 Nov;109(11):1145-51
pubmed: 11713000
Acta Med Scand. 1981;209(1-2):45-9
pubmed: 7193965
J Allergy Clin Immunol. 2007 Sep;120(3):654-8
pubmed: 17765757
HIV Clin Trials. 2003 May-Jun;4(3):150-63
pubmed: 12815555
J Pharmacol Exp Ther. 2009 Feb;328(2):663-70
pubmed: 19017848
Rapid Commun Mass Spectrom. 2002;16(13):1273-5
pubmed: 12112254
Endocrinology. 2007 Jan;148(1):4-12
pubmed: 17008401
Sci Rep. 2018 Apr 12;8(1):5897
pubmed: 29651127
Drug Test Anal. 2018 Nov;10(11-12):1635-1645
pubmed: 30255601
Clin Rheumatol. 1995 Sep;14 Suppl 3:32-9
pubmed: 8846659
N Engl J Med. 2011 May 26;364(21):1995-2005
pubmed: 21612468
J Ethnopharmacol. 2000 Oct;72(3):345-93
pubmed: 10996277
Lancet. 1969 Nov 29;2(7631):1203
pubmed: 4187238
BJU Int. 2012 Jul;110(2):162-9
pubmed: 22288877
Pharm Res. 2006 Aug;23(8):1641-58
pubmed: 16841196
Toxicol Lett. 2006 Aug 20;165(2):149-55
pubmed: 16621347
Neurobiol Stress. 2019 Dec 26;12:100209
pubmed: 32435662
Endocrinology. 2009 Jan;150(1):385-95
pubmed: 18772237
Lancet. 1969 Jun 21;1(7608):1239-40
pubmed: 4182415
Br J Pharmacol. 2008 Jun;154(3):502-21
pubmed: 18500378
Toxicol Lett. 2007 Feb 28;169(1):64-71
pubmed: 17254722
J Steroid Biochem Mol Biol. 2008 Mar;109(1-2):129-37
pubmed: 18164613
Contraception. 2013 Mar;87(3):288-95
pubmed: 23063338
J Int Coll Surg. 1959 Oct;32:359-68
pubmed: 14412180
BMJ Case Rep. 2015 May 06;2015:
pubmed: 25948845
Proc Soc Exp Biol Med. 1950 May;74(1):162-4
pubmed: 15430420
Obstet Gynecol Surv. 2001 Jun;56(6):361-76
pubmed: 11466487
Rapid Commun Mass Spectrom. 2016 Apr 15;30(7):833-42
pubmed: 26969924
Lancet Oncol. 2013 Apr;14(4):335-45
pubmed: 23499390
J Biol Chem. 2009 Dec 25;284(52):36367-76
pubmed: 19846549
Mol Cancer Ther. 2010 Jan;9(1):202-10
pubmed: 20053782
Contraception. 1977 Feb;15(2):151-62
pubmed: 837689
Arzneimittelforschung. 1966 Apr;16(4):469-71
pubmed: 6014252
Steroids. 2010 Jun;75(6):377-89
pubmed: 20138077
Ann Paediatr Fenn. 1966;12(2):89-95
pubmed: 5914311
J Nat Prod. 2009 Dec;72(12):2135-40
pubmed: 19919052
HIV Med. 2006 Apr;7(3):146-55
pubmed: 16494628
Shock. 2016 Apr;45(4):367-74
pubmed: 26506070
Biol Pharm Bull. 2018;41(3):394-398
pubmed: 29491216
Ann Allergy Asthma Immunol. 2004 Mar;92(3):377-8
pubmed: 15049404
J Androl. 2011 Sep-Oct;32(5):530-40
pubmed: 21164142
Mol Cell Endocrinol. 2018 Apr 15;465:134-142
pubmed: 28624515
J Med Chem. 2006 Oct 19;49(21):6143-6
pubmed: 17034117
J Cachexia Sarcopenia Muscle. 2011 Sep;2(3):153-161
pubmed: 22031847
Clin Ther. 2001 Jun;23(6):789-801; discussion 771
pubmed: 11440282
J Ethnopharmacol. 2014 Mar 28;152(3):424-43
pubmed: 24468305
Mol Pharmacol. 2007 Feb;71(2):473-82
pubmed: 17105867
Scand J Haematol. 1979 Apr 4;22(4):343-56
pubmed: 472658
Nutrition. 2002 Sep;18(9):734-7
pubmed: 12297208
Curr Oncol Rep. 2016 Jun;18(6):37
pubmed: 27138015
Andrologia. 2016 Aug;48(6):637-45
pubmed: 26598279
Drugs. 2004;64(7):725-50
pubmed: 15025546
Future Oncol. 2014 Feb;10(2):187-94
pubmed: 24490605
Sci Rep. 2016 Jul 07;6:29136
pubmed: 27385275
Drug Des Devel Ther. 2014 Jan 09;8:101-12
pubmed: 24470750
Endocr Connect. 2020 Mar 1;:
pubmed: 32229704
Andrologia. 2020 Apr;52(3):e13509
pubmed: 31989693
Drug Discov Today. 2007 Mar;12(5-6):241-8
pubmed: 17331889
Breast Cancer Res Treat. 1985;5(1):75-80
pubmed: 3978249
J Drug Target. 2009 Feb;17(2):91-7
pubmed: 19089688
Cancer. 1984 Feb 1;53(3 Suppl):766-77
pubmed: 6229323
Steroids. 1990 Apr;55(4):170-6
pubmed: 2187285
Dis Mon. 2013 Jun;59(6):226-48
pubmed: 23719201
Curr Allergy Asthma Rep. 2012 Aug;12(4):273-80
pubmed: 22729959
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8167-9
pubmed: 11459947
Am J Dis Child. 1969 Nov;118(5):759-64
pubmed: 5348374
Chem Rev. 2005 Sep;105(9):3352-70
pubmed: 16159155
Pediatrics. 1993 Apr;91(4):716-20
pubmed: 8464656
Aging Male. 2020 Mar;23(1):81-92
pubmed: 30782054
Drug Test Anal. 2009 Aug;1(8):387-92
pubmed: 20355219
J Pharmacol Exp Ther. 2003 Mar;304(3):1323-33
pubmed: 12604713