Iron Deficiency in Pulmonary Arterial Hypertension: A Deep Dive into the Mechanisms.
cardiovascular disease
iron deficiency
iron homeostasis
pulmonary arterial hypertension
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
23 02 2021
23 02 2021
Historique:
received:
13
01
2021
revised:
13
02
2021
accepted:
18
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
27
8
2021
Statut:
epublish
Résumé
Pulmonary arterial hypertension (PAH) is a severe cardiovascular disease that is caused by the progressive occlusion of the distal pulmonary arteries, eventually leading to right heart failure and death. Almost 40% of patients with PAH are iron deficient. Although widely studied, the mechanisms linking between PAH and iron deficiency remain unclear. Here we review the mechanisms regulating iron homeostasis and the preclinical and clinical data available on iron deficiency in PAH. Then we discuss the potential implications of iron deficiency on the development and management of PAH.
Identifiants
pubmed: 33672218
pii: cells10020477
doi: 10.3390/cells10020477
pmc: PMC7926484
pii:
doi:
Substances chimiques
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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