Macrophage Function and the Role of GSK3.
atherosclerosis
glycogen synthase kinase (GSK)-3
inflammatory response
macrophage function
molecular mechanisms
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Feb 2021
23 Feb 2021
Historique:
received:
06
02
2021
revised:
18
02
2021
accepted:
19
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
2
6
2021
Statut:
epublish
Résumé
Macrophages are present in nearly all vertebrate tissues, where they respond to a complex variety of regulatory signals to coordinate immune functions involved in tissue development, metabolism, homeostasis, and repair. Glycogen synthase kinase 3 (GSK3) is a ubiquitously expressed protein kinase that plays important roles in multiple pathways involved in cell metabolism. Dysregulation of GSK3 has been implicated in several prevalent metabolic disorders, and recent findings have highlighted the importance of GSK3 activity in the regulation of macrophages, especially with respect to the initiation of specific pathologies. This makes GSK3 a potential therapeutic target for the development of novel drugs to modulate immunometabolic responses. Here, we summarize recent findings that have contributed to our understanding of how GSK3 regulates macrophage function, and we discuss the role of GSK3 in the development of metabolic disorders and diseases.
Identifiants
pubmed: 33672232
pii: ijms22042206
doi: 10.3390/ijms22042206
pmc: PMC7926541
pii:
doi:
Substances chimiques
Glycogen Synthase Kinase 3
EC 2.7.11.26
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : PJT-166092
Pays : Canada
Organisme : Heart and Stroke Foundation of Canada
ID : G20-0029355
Références
Immunol Rev. 2014 Nov;262(1):153-66
pubmed: 25319333
Int J Alzheimers Dis. 2011;2011:985085
pubmed: 21629716
Adv Biol Regul. 2017 Aug;65:5-15
pubmed: 28712664
Arterioscler Thromb Vasc Biol. 2015 May;35(5):1113-22
pubmed: 25767272
Mol Cell Biol. 2008 Oct;28(20):6314-28
pubmed: 18694957
Cell Res. 2014 Jun;24(6):742-61
pubmed: 24777252
Front Mol Neurosci. 2011 Nov 16;4:40
pubmed: 22110425
J Am Coll Cardiol. 2018 Oct 30;72(18):2213-2230
pubmed: 30360829
Semin Immunopathol. 2013 Sep;35(5):563-83
pubmed: 23864058
Nature. 2000 Jul 6;406(6791):86-90
pubmed: 10894547
Am J Pathol. 2012 Oct;181(4):1414-25
pubmed: 22863953
Cytokine. 2018 Aug;108:89-95
pubmed: 29587154
Front Immunol. 2014 Oct 07;5:491
pubmed: 25339958
J Biol Chem. 2007 Jun 1;282(22):16502-10
pubmed: 17403689
Front Microbiol. 2019 Dec 05;10:2828
pubmed: 31866988
J Biol Chem. 2008 Aug 8;283(32):21934-44
pubmed: 18550525
Front Immunol. 2014 Sep 02;5:420
pubmed: 25228902
EMBO J. 1990 Aug;9(8):2431-8
pubmed: 2164470
Chem Rev. 2001 Aug;101(8):2527-40
pubmed: 11749387
Diabetes. 2000 Feb;49(2):263-71
pubmed: 10868943
Cells. 2019 May 22;8(5):
pubmed: 31121982
Cell. 2019 Apr 18;177(3):541-555.e17
pubmed: 30955887
Immunity. 2014 Jul 17;41(1):21-35
pubmed: 25035951
Front Physiol. 2018 May 01;9:419
pubmed: 29765329
J Immunol. 2011 Feb 1;186(3):1391-8
pubmed: 21191064
Pharmacol Ther. 2015 Apr;148:114-31
pubmed: 25435019
Elife. 2018 Oct 15;7:
pubmed: 30320549
Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8455-9
pubmed: 8710892
Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15;307(10):L735-45
pubmed: 25239914
Nat Rev Immunol. 2011 Oct 25;11(11):750-61
pubmed: 22025054
FASEB J. 2011 Mar;25(3):1076-87
pubmed: 21097520
J Clin Invest. 2008 Nov;118(11):3609-18
pubmed: 18830417
Cell Biol Int. 2015 Feb;39(2):192-200
pubmed: 25229877
Nature. 2003 May 22;423(6938):435-9
pubmed: 12761548
J Immunol. 2008 Nov 15;181(10):6797-802
pubmed: 18981097
Nat Rev Immunol. 2008 Dec;8(12):958-69
pubmed: 19029990
Joint Bone Spine. 2014 May;81(3):240-6
pubmed: 24176738
Cell Metab. 2007 Oct;6(4):329-37
pubmed: 17908561
J Neurochem. 2002 Jun;81(5):1073-83
pubmed: 12065620
FEBS Lett. 1994 Jan 24;338(1):37-42
pubmed: 8307153
Cells. 2018 Dec 07;7(12):
pubmed: 30544623
J Cell Biochem. 2010 Dec 15;111(6):1522-30
pubmed: 20872791
Sci Transl Med. 2018 Mar 7;10(431):
pubmed: 29515000
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11074-9
pubmed: 10995469
Nat Commun. 2015 Apr 01;6:6765
pubmed: 25828701
J Cell Sci. 2014 Apr 1;127(Pt 7):1369-78
pubmed: 24687186
Cell Oncol (Dordr). 2020 Aug;43(4):643-654
pubmed: 32227296
Biochem Pharmacol. 2019 Jul;165:207-213
pubmed: 30776323
Oxid Med Cell Longev. 2017;2017:4629495
pubmed: 29379583
Cell Host Microbe. 2020 Jan 8;27(1):41-53.e6
pubmed: 31862381
J Hepatol. 2018 Jul;69(1):99-109
pubmed: 29452207
Exp Hematol. 2010 Oct;38(10):908-921.e1
pubmed: 20540984
Biol Pharm Bull. 2019;42(6):968-976
pubmed: 31155593
Am J Pathol. 2014 Dec;184(12):3394-404
pubmed: 25451156
Nat Immunol. 2016 Jan;17(1):26-33
pubmed: 26681459
J Biol Chem. 2007 Dec 14;282(50):36230-9
pubmed: 17951252
Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9415-20
pubmed: 23690624
Trends Immunol. 2010 Jan;31(1):24-31
pubmed: 19836308
Immunity. 2019 Sep 17;51(3):522-534.e7
pubmed: 31471107
Cell Signal. 2008 Apr;20(4):726-36
pubmed: 18234473
Drug Discov Today. 2017 Jan;22(1):186-193
pubmed: 27554801
J Cell Sci. 2008 Nov 1;121(Pt 21):3598-607
pubmed: 18946023
Int Immunopharmacol. 2019 Jun;71:198-204
pubmed: 30913518
PLoS Negl Trop Dis. 2012;6(3):e1446
pubmed: 22479654
Protein Cell. 2012 Oct;3(10):762-8
pubmed: 22983902
J Lipid Res. 2014 Nov;55(11):2320-33
pubmed: 25183803
Hepatology. 2011 Aug;54(2):687-96
pubmed: 21567437
PLoS One. 2011 Jan 06;6(1):e15845
pubmed: 21253590
Biochem J. 1994 Nov 1;303 ( Pt 3):701-4
pubmed: 7980435
Exp Cell Res. 1993 Aug;207(2):321-31
pubmed: 8344384
Nature. 1995 Dec 21-28;378(6559):785-9
pubmed: 8524413
Nat Immunol. 2011 May 22;12(7):607-15
pubmed: 21602809
Exp Neurol. 2015 Oct;272:135-44
pubmed: 25585014
J Clin Invest. 2003 Dec;112(12):1796-808
pubmed: 14679176
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11960-5
pubmed: 11035810
Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2103-2116
pubmed: 30026270
Nat Immunol. 2005 Aug;6(8):777-84
pubmed: 16007092
Leukemia. 2013 Feb;27(2):315-24
pubmed: 22751450