Individualized Hemodynamic Management in Sepsis.
early goal-directed therapy
fluid therapy
hemodynamic monitoring
lactate
septic shock
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
23 Feb 2021
23 Feb 2021
Historique:
received:
20
01
2021
revised:
13
02
2021
accepted:
18
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
Hemodynamic optimization remains the cornerstone of resuscitation in the treatment of sepsis and septic shock. Delay or inadequate management will inevitably lead to hypoperfusion, tissue hypoxia or edema, and fluid overload, leading eventually to multiple organ failure, seriously affecting outcomes. According to a large international survey (FENICE study), physicians frequently use inadequate indices to guide fluid management in intensive care units. Goal-directed and "restrictive" infusion strategies have been recommended by guidelines over "liberal" approaches for several years. Unfortunately, these "fixed regimen" treatment protocols neglect the patient's individual needs, and what is shown to be beneficial for a given population may not be so for the individual patient. However, applying multimodal, contextualized, and personalized management could potentially overcome this problem. The aim of this review was to give an insight into the pathophysiological rationale and clinical application of this relatively new approach in the hemodynamic management of septic patients.
Identifiants
pubmed: 33672267
pii: jpm11020157
doi: 10.3390/jpm11020157
pmc: PMC7926902
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : European Regional Development Fund
ID : GINOP-2.3.2-15-2016-00048 - STAY ALIVE
Organisme : European Regional Development Fund
ID : EFOP 3.6.2-16-2017-00006 - LIVE LONGER
Références
Crit Care. 2015 Jun 15;19:251
pubmed: 26073560
PLoS One. 2017 Nov 27;12(11):e0188548
pubmed: 29176794
Nat Med. 2018 Nov;24(11):1716-1720
pubmed: 30349085
Anesth Analg. 2020 Feb;130(2):352-359
pubmed: 30896602
Intensive Care Med. 2011 May;37(5):801-7
pubmed: 21373821
Ann Emerg Med. 2010 Jan;55(1):40-46.e1
pubmed: 19854541
Crit Care. 2015;19 Suppl 3:S8
pubmed: 26729241
Intensive Care Med. 2013 Feb;39(2):165-228
pubmed: 23361625
J Clin Monit Comput. 2018 Jun;32(3):375-377
pubmed: 28653134
J Crit Care. 2017 Dec;42:200-205
pubmed: 28772222
Crit Care Med. 2020 Dec;48(12):1855-1861
pubmed: 33003080
Anesthesiology. 2018 Oct;129(4):663-674
pubmed: 29894315
N Engl J Med. 2001 Nov 8;345(19):1368-77
pubmed: 11794169
Am J Respir Crit Care Med. 2019 Sep 1;200(5):582-589
pubmed: 30985210
J Cardiothorac Vasc Anesth. 2019 Aug;33 Suppl 1:S67-S72
pubmed: 31279355
Crit Care Med. 2013 Feb;41(2):472-80
pubmed: 23263578
Cochrane Database Syst Rev. 2013 Feb 28;(2):CD003408
pubmed: 23450539
Nat Rev Immunol. 2013 Dec;13(12):862-74
pubmed: 24232462
Ann Card Anaesth. 2014 Oct-Dec;17(4):273-7
pubmed: 25281622
JAMA. 2016 Feb 23;315(8):801-10
pubmed: 26903338
Minerva Anestesiol. 2006 Jun;72(6):597-604
pubmed: 16682934
Br J Anaesth. 2020 Oct;125(4):419-423
pubmed: 32690244
J Intensive Care. 2019 Sep 05;7:47
pubmed: 31516712
Intensive Care Med. 2015 Sep;41(9):1529-37
pubmed: 26162676
Intensive Care Med. 2019 Jan;45(1):21-32
pubmed: 30456467
Crit Care Clin. 2015 Jan;31(1):89-111
pubmed: 25435480
J Clin Monit Comput. 2015 Dec;29(6):807-13
pubmed: 25726179
Crit Care Med. 2006 Feb;34(2):344-53
pubmed: 16424713
Chest. 2018 Jan;153(1):55-64
pubmed: 28866112
Crit Care. 2019 Jun 10;23(1):211
pubmed: 31182133
Ann Intensive Care. 2020 Nov 2;10(1):150
pubmed: 33140173
J Crit Care. 2020 Dec;60:334-336
pubmed: 32741525
N Engl J Med. 2014 Oct 16;371(16):1496-506
pubmed: 25272316
Br J Anaesth. 2017 Mar 1;118(3):298-310
pubmed: 28203792
JAMA. 2019 Feb 19;321(7):654-664
pubmed: 30772908
J Clin Monit Comput. 1999 Aug;15(6):387-401
pubmed: 12578034
JAMA. 2016 Feb 23;315(8):775-87
pubmed: 26903336
Ann Intensive Care. 2016 Dec;6(1):15
pubmed: 26885656
J Cell Mol Med. 2020 Jun;24(11):6485-6494
pubmed: 32352229
Crit Care. 2014 Sep 09;18(5):503
pubmed: 25394679
Crit Care Med. 2012 Apr;40(4):1177-85
pubmed: 22202713
J Clin Monit Comput. 2018 Jun;32(3):403-414
pubmed: 28593456
Intensive Care Med. 2017 Mar;43(3):304-377
pubmed: 28101605
Crit Care. 2011;15(5):232
pubmed: 22047813
Anesthesiology. 2020 Nov 1;133(5):964-966
pubmed: 32946546
Crit Care Med. 1989 May;17(5):389-93
pubmed: 2651003
Crit Care Med. 2009 Mar;37(3):934-8
pubmed: 19237899
Crit Care Med. 2015 Jul;43(7):1423-8
pubmed: 25844700
Chest. 2018 Dec;154(6):1291-1300
pubmed: 29787743
Crit Care Med. 2015 Mar;43(3):567-73
pubmed: 25479113
N Engl J Med. 2014 May 1;370(18):1683-93
pubmed: 24635773
Front Med (Lausanne). 2017 Nov 20;4:200
pubmed: 29230392
Crit Care Med. 1999 Jul;27(7):1369-77
pubmed: 10446833
N Engl J Med. 2015 Apr 2;372(14):1301-11
pubmed: 25776532