Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants.
adjuvant therapies
antimicrobial resistance
cysteine biosynthesis
non-essential targets
serine acetyltransferase
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
23 Feb 2021
23 Feb 2021
Historique:
received:
26
01
2021
revised:
15
02
2021
accepted:
19
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
Many bacteria and actinomycetales use L-cysteine biosynthesis to increase their tolerance to antibacterial treatment and establish a long-lasting infection. In turn, this might lead to the onset of antimicrobial resistance that currently represents one of the most menacing threats to public health worldwide. The biosynthetic machinery required to synthesise L-cysteine is absent in mammals; therefore, its exploitation as a drug target is particularly promising. In this article, we report a series of inhibitors of
Identifiants
pubmed: 33672408
pii: ph14020174
doi: 10.3390/ph14020174
pmc: PMC7931047
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Academy of Finland
ID : 277001
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