A New Controlled Release System for Propolis Polyphenols and Its Biochemical Activity for Skin Applications.
controlled release
liposome
polyphenols
propolis
Journal
Plants (Basel, Switzerland)
ISSN: 2223-7747
Titre abrégé: Plants (Basel)
Pays: Switzerland
ID NLM: 101596181
Informations de publication
Date de publication:
23 Feb 2021
23 Feb 2021
Historique:
received:
05
02
2021
revised:
17
02
2021
accepted:
19
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
Propolis is a resinous substance produced by bees that exhibits antimicrobial, immunostimulatory and antioxidant activity. Its use is common in functional foods, cosmetics and traditional medicine despite the fact that it demonstrates low extraction yields and inconsistency in non-toxic solvents. In this work, a new encapsulation and delivery system consisting of liposomes and cyclodextrins incorporating propolis polyphenols has been developed and characterized. The antioxidant, antimutagenic and antiaging properties of the system under normal and UVB-induced oxidative stress conditions were investigated in cultured skin cells and/or reconstituted skin model. Furthermore, the transcript accumulation for an array of genes involved in many skin-related processes was studied. The system exhibits significant polyphenol encapsulation efficiency, physicochemical stability as well as controlled release rate in appropriate conditions. The delivery system can retain the anti-mutagenic, anti-oxidative and anti-ageing effects of propolis polyphenols to levels similar and comparable to those of propolis methanolic extracts, making the system ideal for applications where non-toxic solvents are required and controlled release of the polyphenol content is desired.
Identifiants
pubmed: 33672417
pii: plants10020420
doi: 10.3390/plants10020420
pmc: PMC7927051
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : "Greece-China Bilateral R&D Cooperation 2013-2015" NSFR grant (Project Nr. 12CHN167).
ID : 12CHN167
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