YM155 Inhibits NleB and SseK Arginine Glycosyltransferase Activity.
enteric bacteria
glycosyltransferase
type three secretion system effectors
Journal
Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317
Informations de publication
Date de publication:
23 Feb 2021
23 Feb 2021
Historique:
received:
12
01
2021
revised:
10
02
2021
accepted:
21
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
The type III secretion system effector proteins NleB and SseK are glycosyltransferases that glycosylate protein substrates on arginine residues. We conducted high-throughput screening assays on 42,498 compounds to identify NleB/SseK inhibitors. Such small molecules may be useful as mechanistic probes and may have utility in the eventual development of anti-virulence therapies against enteric bacterial pathogens. We observed that YM155 (sepantronium bromide) inhibits the activity of
Identifiants
pubmed: 33672424
pii: pathogens10020253
doi: 10.3390/pathogens10020253
pmc: PMC7926936
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIH HHS
ID : P20GM113117
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM113117
Pays : United States
Organisme : NIH HHS
ID : P20GM130448
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103638
Pays : United States
Organisme : NIH HHS
ID : P20GM103638
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI153202
Pays : United States
Organisme : CMLD Legacy
ID : GM111385
Organisme : NIH HHS
ID : AI153202
Pays : United States
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