Spike S2 Subunit: The Dark Horse in the Race for Prophylactic and Therapeutic Interventions against SARS-CoV-2.
COVID-19
S2 subunit
SARS-CoV-2
coronavirus disease 2019
severe acute respiratory syndrome coronavirus 2
spike glycoprotein
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
20 Feb 2021
20 Feb 2021
Historique:
received:
29
01
2021
revised:
15
02
2021
accepted:
18
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
In the midst of the unceasing COVID-19 pandemic, the identification of immunogenic epitopes in the SARS-CoV-2 spike (S) glycoprotein plays a vital role in the advancement and development of intervention strategies. S is expressed on the exterior of the SARS-CoV-2 virion and contains two subunits, namely the N-terminal S1 and C-terminal S2. It is the key element for mediating viral entry as well as a crucial antigenic determinant capable of stimulating protective immune response through elicitation of anti-SARS-CoV-2 antibodies and activation of CD4
Identifiants
pubmed: 33672450
pii: vaccines9020178
doi: 10.3390/vaccines9020178
pmc: PMC7923282
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NUHS Research Office
ID : NUHSRO/2020/033/ RO5+5/CORONAVIRUS/LOA (WBS R-571-000-071-733)
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