Immunological Risk Factors in Recurrent Pregnancy Loss: Guidelines Versus Current State of the Art.
NK cells
recurrent miscarriage
regulatory T cells
reproductive immunology
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
20 Feb 2021
20 Feb 2021
Historique:
received:
29
11
2020
revised:
13
02
2021
accepted:
15
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
Around 1-5% of all couples experience recurrent pregnancy loss (RPL). Established risk factors include anatomical, genetic, endocrine, and hemostatic alterations. With around 50% of idiopathic cases, immunological risk factors are getting into the scientific focus, however international guidelines hardly take them into account. Within this review, the current state of immunological risk factors in RPL in international guidelines of the European Society of Reproduction and Embryology (ESHRE), American Society of Reproductive Medicine (ASRM), German/Austrian/Swiss Society of Obstetrics and Gynecology (DGGG/OEGGG/SGGG) and the Royal College of Obstetricians and Gynecologists (RCOG) are evaluated. Special attention was drawn to recommendations in the guidelines regarding diagnostic factors such as autoantibodies, natural killer cells, regulatory T cells, dendritic cells, plasma cells, and human leukocyte antigen system (HLA)-sharing as well as treatment options such as corticosteroids, intralipids, intravenous immunoglobulins, aspirin and heparin in RPL. Finally, the current state of the art focusing on both diagnostic and therapeutic options was summarized.
Identifiants
pubmed: 33672505
pii: jcm10040869
doi: 10.3390/jcm10040869
pmc: PMC7923780
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Tiroler Wissenschaftsförderung
ID : F.16962/5-2019
Organisme : Austrian Science Fund
ID : 33249-B
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