Unmet Medical Needs and Future Perspectives for Leiomyosarcoma Patients-A Position Paper from the National LeioMyoSarcoma Foundation (NLMSF) and Sarcoma Patients EuroNet (SPAEN).

NLMSF SPAEN leiomyosarcoma research treatment

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
20 Feb 2021
Historique:
received: 29 01 2021
revised: 11 02 2021
accepted: 15 02 2021
entrez: 6 3 2021
pubmed: 7 3 2021
medline: 7 3 2021
Statut: epublish

Résumé

As leiomyosarcoma patients are challenged by the development of metastatic disease, effective systemic therapies are the cornerstone of outcome. However, the overall activity of the currently available conventional systemic treatments and the prognosis of patients with advanced or metastatic disease are still poor, making the treatment of this patient group challenging. Therefore, in a joint effort together with patient networks and organizations, namely Sarcoma Patients EuroNet (SPAEN), the international network of sarcoma patients organizations, and the National LeioMyoSarcoma Foundation (NLMSF) in the United States, we aim to summarize state-of-the-art treatments for leiomyosarcoma patients in order to identify knowledge gaps and current unmet needs, thereby guiding the community to design innovative clinical trials and basic research and close these research gaps. This position paper arose from a leiomyosarcoma research meeting in October 2020 hosted by the NLMSF and SPAEN.

Identifiants

pubmed: 33672607
pii: cancers13040886
doi: 10.3390/cancers13040886
pmc: PMC7924026
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

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Auteurs

Bernd Kasper (B)

Mannheim University Medical Center, University of Heidelberg, 68167 Mannheim, Germany.

Annie Achee (A)

National LeioMyoSarcoma Foundation (NLMSF), Denver, CO 80222, USA.

Kathrin Schuster (K)

Sarcoma Patients EuroNet, SPAEN, 61200 Wölfersheim, Germany.

Roger Wilson (R)

Sarcoma Patients EuroNet, SPAEN, 61200 Wölfersheim, Germany.

Gerard van Oortmerssen (G)

Sarcoma Patients EuroNet, SPAEN, 61200 Wölfersheim, Germany.

Rebecca A Gladdy (RA)

Department of Surgery, Mount Sinai Hospital, Toronto, ON M5G 1XS, Canada.

Matthew L Hemming (ML)

Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Paul Huang (P)

Institute of Cancer Research, London SM2 5NG, UK.

Matthew Ingham (M)

Department of Medicine, Columbia University School of Medicine, New York, NY 10032, USA.

Robin L Jones (RL)

Institute of Cancer Research, London SM2 5NG, UK.
Royal Marsden Hospital, London SW3 6JJ, UK.

Seth M Pollack (SM)

Northwestern Medicine, Feinberg School of Medicine, Chicago, IL 60611, USA.

Denise Reinke (D)

Sarcoma Alliance for Research through Collaboration (SARC), Ann Arbor, MI 48105, USA.

Roberta Sanfilippo (R)

Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.

Scott M Schuetze (SM)

Michigan Medicine Sarcoma Clinic, Rogel Cancer Center, Ann Arbor, MI 48109, USA.

Neeta Somaiah (N)

Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Care Center, Houston, TX 77030, USA.

Brian A Van Tine (BA)

Barnes and Jewish Hospital, Washington University in St. Louis, St. Louis, MO 63110, USA.

Breelyn Wilky (B)

Department of Sarcoma Medical Oncology, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.

Scott Okuno (S)

Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA.

Jonathan Trent (J)

Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA.

Classifications MeSH