Molecular Regulation of Canalicular ABC Transporters.
ABCB1
ABCB11
ABCB4
ABCC2
ABCG5/G8
bile secretion
molecular partners
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Feb 2021
20 Feb 2021
Historique:
received:
01
02
2021
revised:
15
02
2021
accepted:
18
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
15
4
2021
Statut:
epublish
Résumé
The ATP-binding cassette (ABC) transporters expressed at the canalicular membrane of hepatocytes mediate the secretion of several compounds into the bile canaliculi and therefore play a key role in bile secretion. Among these transporters, ABCB11 secretes bile acids, ABCB4 translocates phosphatidylcholine and ABCG5/G8 is responsible for cholesterol secretion, while ABCB1 and ABCC2 transport a variety of drugs and other compounds. The dysfunction of these transporters leads to severe, rare, evolutionary biliary diseases. The development of new therapies for patients with these diseases requires a deep understanding of the biology of these transporters. In this review, we report the current knowledge regarding the regulation of canalicular ABC transporters' folding, trafficking, membrane stability and function, and we highlight the role of molecular partners in these regulating mechanisms.
Identifiants
pubmed: 33672718
pii: ijms22042113
doi: 10.3390/ijms22042113
pmc: PMC7924332
pii:
doi:
Substances chimiques
ABCC2 protein, human
0
ATP-Binding Cassette Transporters
0
Multidrug Resistance-Associated Protein 2
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-15-CE14-0008-01
Organisme : Association Française pour l'Etude du Foie
ID : XXX
Organisme : Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation
ID : XXX
Organisme : German Research Foundation
ID : 403224013
Organisme : Fondation pour la Recherche Médicale
ID : FRM-EQU-2020-03010517
Organisme : Association Mucoviscidose-ABCF2
ID : XXX
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