Surveillance as Determinant of Long-Term Survival in Non-Transplanted Hepatocellular Carcinoma Patients.

cancer stage hepatocellular carcinoma long-term survival surveillance treatment

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
20 Feb 2021
Historique:
received: 03 02 2021
accepted: 18 02 2021
entrez: 6 3 2021
pubmed: 7 3 2021
medline: 7 3 2021
Statut: epublish

Résumé

We aimed at assessing the impact of surveillance on long-term survival in HCC patients. From the ITA.LI.CA database, we selected 1028 cases with long (≥5 years, LS group) and 2721 controls with short-term survival (<5 years, SS group). The association between surveillance and LS was adjusted for confounders by multivariable logistic regression analysis. Survival of surveilled patients was presented both as observed and corrected for the lead-time bias, and the comparison of survival between surveillance and no surveillance groups was also performed after balancing the baseline characteristics with inverse probability weights (IPW). LS patients were more frequently diagnosed under surveillance ( Surveillance, increasing early-stage diagnosis and applicability of curative treatments, is a fundamental determinant of long-term survival in HCC patients. A wide implementation of surveillance programs should be pursued in order to improve HCC patients' prognosis.

Identifiants

pubmed: 33672751
pii: cancers13040897
doi: 10.3390/cancers13040897
pmc: PMC7924561
pii:
doi:

Types de publication

Journal Article

Langues

eng

Références

World J Gastroenterol. 2013 Jun 21;19(23):3649-57
pubmed: 23801868
PLoS Med. 2014 Apr 01;11(4):e1001624
pubmed: 24691105
Am J Gastroenterol. 2002 Mar;97(3):734-44
pubmed: 11922571
Hepatology. 2015 Aug;62(2):440-51
pubmed: 25678263
Hepatology. 2010 Apr;51(4):1274-83
pubmed: 20112254
Br J Cancer. 2008 Apr 8;98(7):1166-75
pubmed: 18382459
N Engl J Med. 2008 Nov 6;359(19):1995-2004
pubmed: 18923165
Ann Intern Med. 2011 Jan 18;154(2):85-93
pubmed: 21242365
J Hepatol. 2010 Aug;53(2):291-7
pubmed: 20483497
Hepatology. 2000 Aug;32(2):233-8
pubmed: 10915729
Gastroenterology. 2019 Jul;157(1):54-64
pubmed: 30986389
J Cancer Res Clin Oncol. 2004 Jul;130(7):417-22
pubmed: 15042359
Hepatol Res. 2016 Nov;46(12):1275-1280
pubmed: 26879882
J Cancer Res Clin Oncol. 1997;123(6):357-60
pubmed: 9222303
World J Gastroenterol. 2013 Dec 21;19(47):8808-21
pubmed: 24379604
Hepatology. 2018 Aug;68(2):723-750
pubmed: 29624699
Liver Int. 2018 Sep;38(9):1624-1634
pubmed: 29791968
Blood. 2003 Jul 1;102(1):78-82
pubmed: 12649165
Dig Liver Dis. 2010 Sep;42(9):642-9
pubmed: 20381438
Ann Oncol. 2013 Oct;24(10):2565-2570
pubmed: 23857958
J Hepatol. 2015 Jun;62(6):1304-10
pubmed: 25637785
Aliment Pharmacol Ther. 2009 Jul;30(1):37-47
pubmed: 19392863
Liver Int. 2015 Jan;35(1):223-31
pubmed: 25074434
Lancet. 2003 Mar 15;361(9361):923-9
pubmed: 12648972
Korean J Hepatobiliary Pancreat Surg. 2012 Aug;16(3):98-104
pubmed: 26388916
Gut. 2016 May;65(5):861-9
pubmed: 25666192
J Gen Intern Med. 2012 Jul;27(7):861-7
pubmed: 22215266
J Sch Psychol. 2010 Feb;48(1):5-37
pubmed: 20006986
Liver Int. 2015 Sep;35(9):2155-66
pubmed: 25752327
Am J Gastroenterol. 2007 Nov;102(11):2448-57; quiz 2458
pubmed: 17617210
Hepatology. 2020 Dec;72(6):2206-2218
pubmed: 32064645
Stat Med. 2013 Aug 30;32(19):3388-414
pubmed: 23508673
Liver Int. 2019 Aug;39(8):1478-1489
pubmed: 31131974
Hepatology. 2015 Jan;61(1):184-90
pubmed: 25234419
Liver Int. 2021 Mar;41(3):585-597
pubmed: 33219585
Hepatology. 1999 Jan;29(1):62-7
pubmed: 9862851
Hepatology. 2013 Dec;58(6):2045-55
pubmed: 23775876
J Hepatol. 2018 Jul;69(1):182-236
pubmed: 29628281
Anticancer Res. 2014 Feb;34(2):1047-52
pubmed: 24511053
J Hepatol. 2015 Mar;62(3):617-24
pubmed: 25450706
Gut. 2017 Feb;66(2):342-351
pubmed: 26669617
Hepatology. 2018 Jan;67(1):358-380
pubmed: 28130846
J Hepatol. 2014 Aug;61(2):333-41
pubmed: 24717522
Cancer. 2011 Jan 1;117(1):125-33
pubmed: 21058409
Ann Surg Oncol. 2019 Nov;26(12):4126-4133
pubmed: 31359277
Aliment Pharmacol Ther. 2013 Oct;38(7):703-12
pubmed: 23957569
PLoS Med. 2016 Apr 26;13(4):e1002006
pubmed: 27116206
Ann Surg Oncol. 2017 May;24(5):1358-1366
pubmed: 27921192
Hepatology. 2018 May;67(5):1784-1796
pubmed: 29159910
Hepatology. 2018 Jun;67(6):2215-2225
pubmed: 29165831
J Clin Gastroenterol. 2013 Jul;47 Suppl:S2-6
pubmed: 23632345
J Gastrointestin Liver Dis. 2018 Dec;27(4):399-407
pubmed: 30574622
Liver Int. 2017 Feb;37(2):259-270
pubmed: 27427866

Auteurs

Filippo Pelizzaro (F)

Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy.

Alessandro Vitale (A)

Hepatobiliary Surgery and Liver Transplantation Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy.

Anna Sartori (A)

Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy.

Andrea Vieno (A)

Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy.

Barbara Penzo (B)

Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy.

Francesco Paolo Russo (FP)

Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy.

Anna Chiara Frigo (AC)

Biostatistics Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, Italy.

Edoardo G Giannini (EG)

Gastroenterology Unit, Department of Internal Medicine, University of Genova, IRCCS Policlinico San Martino, 16132 Genova, Italy.

Manuela Piccinnu (M)

Internal Medicine-Piscaglia Unit, Department of Medical and Surgical Sciences, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40126 Bologna, Italy.

Gian Ludovico Rapaccini (GL)

Gastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, Italy.

Maria Di Marco (M)

Medicine Unit, Bolognini Hospital, 24068 Seriate, Italy.

Eugenio Caturelli (E)

Gastroenterology Unit, Belcolle Hospital, 01100 Viterbo, Italy.

Marco Zoli (M)

Internal Medicine-Zoli Unit, Department of Medical and Surgical Sciences, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40126 Bologna, Italy.

Rodolfo Sacco (R)

Gastroenterology and Digestive Endoscopy Unit, Foggia University Hospital, 71122 Foggia, Italy.

Ciro Celsa (C)

Gastroenterology & Hepatology Unit, Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, PROMISE, University of Palermo, 90133 Palermo, Italy.

Fabio Marra (F)

Internal Medicine and Hepatology Unit, Department of Experimental and Clinical Medicine, University of Firenze, 50121 Firenze, Italy.

Andrea Mega (A)

Gastroenterology Unit, Bolzano Regional Hospital, 39100 Bolzano, Italy.

Maria Guarino (M)

Gastroenterology Unit, Department of Clinical Medicine and Surgery, University of Napoli "Federico II", 80138 Napoli, Italy.

Antonio Gasbarrini (A)

Internal Medicine and Gastroenterology Unit, Policlinico Gemelli, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.

Gianluca Svegliati-Baroni (G)

Gastroenterology Unit, Polytechnic University of Marche, 60121 Ancona, Italy.

Francesco Giuseppe Foschi (FG)

Department of Internal Medicine, Ospedale per gli Infermi di Faenza, 48018 Faenza, Italy.

Andrea Olivani (A)

Infectious Diseases and Hepatology Unit, Azienda Ospedaliero-Universitaria di Parma, 43126 Parma, Italy.

Alberto Masotto (A)

Gastroenterology Unit, Ospedale Sacro Cuore Don Calabria, 37024 Negrar, Italy.

Pietro Coccoli (P)

Hepato-Gastroenterology Unit, Department of Clinical Medicine and Surgery, University of Napoli "Federico II", 80138 Napoli, Italy.

Giovanni Raimondo (G)

Clinical and Molecular Hepatology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy.

Francesco Azzaroli (F)

Gastroenterology Unit, Department of Surgical and Medical Sciences, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40126 Bologna, Italy.

Gianpaolo Vidili (G)

Clinica Medica Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Azienda Ospedaliero-Universitaria di Sassari, 07100 Sassari, Italy.

Maurizia Rossana Brunetto (MR)

Department of Clinical and Experimental Medicine, Hepatology and Liver Physiopathology Laboratory and Internal Medicine, University of Pisa, 56126 Pisa, Italy.

Franco Trevisani (F)

Medical Semeiotics Unit, Department of Medical and Surgical Sciences, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.

Fabio Farinati (F)

Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, Italy.

Classifications MeSH