Intestinal Epithelial Barrier Maturation by Enteric Glial Cells Is GDNF-Dependent.
Animals
Caco-2 Cells
Cells, Cultured
Coculture Techniques
Culture Media, Conditioned
/ pharmacology
Enteric Nervous System
/ drug effects
Glial Cell Line-Derived Neurotrophic Factor
/ genetics
Humans
Intestinal Mucosa
/ drug effects
Intestine, Small
/ cytology
Male
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Neuroglia
/ drug effects
Permeability
/ drug effects
Recombinant Proteins
/ pharmacology
Tumor Necrosis Factor-alpha
/ pharmacology
GDNF5
RET6
enteric glial cells
enteric nervous system
gut barrier
inflammatory bowel disease
intercellular junctions
intestinal epithelial barrier
neurotrophic factors
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Feb 2021
14 Feb 2021
Historique:
received:
10
01
2021
revised:
05
02
2021
accepted:
08
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
20
4
2021
Statut:
epublish
Résumé
Enteric glial cells (EGCs) of the enteric nervous system are critically involved in the maintenance of intestinal epithelial barrier function (IEB). The underlying mechanisms remain undefined. Glial cell line-derived neurotrophic factor (GDNF) contributes to IEB maturation and may therefore be the predominant mediator of this process by EGCs. Using GFAP
Identifiants
pubmed: 33672854
pii: ijms22041887
doi: 10.3390/ijms22041887
pmc: PMC7917776
pii:
doi:
Substances chimiques
Culture Media, Conditioned
0
Glial Cell Line-Derived Neurotrophic Factor
0
Recombinant Proteins
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SPP 1782
Organisme : Deutsche Forschungsgemeinschaft
ID : WE4205/3-1
Organisme : ImmunoSensation2 Cluster of Excellence
ID : EXC2151-190873048
Organisme : Interdisziplinaere Zentrum fuer Klinische Forschung Würzburg
ID : Z-2/63
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