Loliolide, a New Therapeutic Option for Neurological Diseases? In Vitro Neuroprotective and Anti-Inflammatory Activities of a Monoterpenoid Lactone Isolated from
Animals
Anti-Inflammatory Agents
/ chemistry
Benzofurans
/ chemistry
Cell Line, Tumor
Chlorophyta
/ chemistry
Cytokines
/ metabolism
DNA Fragmentation
/ drug effects
Humans
Lactones
/ chemistry
Macrophages
/ cytology
Membrane Potential, Mitochondrial
/ drug effects
Mice
Molecular Structure
Monoterpenes
/ chemistry
NF-kappa B
/ metabolism
Neurodegenerative Diseases
/ drug therapy
Neuroprotective Agents
/ chemistry
Nitric Oxide
/ metabolism
RAW 264.7 Cells
Reactive Oxygen Species
/ metabolism
NF-kB pathway
Parkinson’s disease
antioxidant activity
inflammation
marine natural products
neuroprotection
oxidative stress
seaweeds
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Feb 2021
14 Feb 2021
Historique:
received:
14
01
2021
revised:
03
02
2021
accepted:
10
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
20
4
2021
Statut:
epublish
Résumé
Parkinsons Disease (PD) is the second most common neurodegenerative disease worldwide, and is characterized by a progressive degeneration of dopaminergic neurons. Without an effective treatment, it is crucial to find new therapeutic options to fight the neurodegenerative process, which may arise from marine resources. Accordingly, the goal of the present work was to evaluate the ability of the monoterpenoid lactone Loliolide, isolated from the green seaweed
Identifiants
pubmed: 33672866
pii: ijms22041888
doi: 10.3390/ijms22041888
pmc: PMC7918146
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Benzofurans
0
Cytokines
0
Lactones
0
Monoterpenes
0
NF-kappa B
0
Neuroprotective Agents
0
Reactive Oxygen Species
0
Nitric Oxide
31C4KY9ESH
loliolide
U3BB4IM281
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundação para a Ciência e a Tecnologia
ID : UID/04292/2020
Organisme : Fundação para a Ciência e a Tecnologia
ID : UIDP/04046/2020
Organisme : Fundação para a Ciência e a Tecnologia
ID : UIDB/04046/2020
Organisme : Fundação para a Ciência e a Tecnologia
ID : PTDC/BIA-OUT/29250/2017
Organisme : Fundação para a Ciência e a Tecnologia
ID : PTDC/ BIA-BQM/28355/2017
Organisme : European Regional Development Fund
ID : PTDC/ BIA-BQM/28355/2017
Organisme : European Regional Development Fund
ID : Centro-01-0145-FEDER-000018
Organisme : Programa Operacional Regional do Centro
ID : POCI-01-0145-FEDER-029250
Organisme : Fundação para a Ciência e a Tecnologia
ID : SFRH/BD/103255/2014
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