Fungi-Bacteria Correlation in Alcoholic Hepatitis Patients.
Adult
Aged
Bacteria
/ genetics
Case-Control Studies
Dysbiosis
Feces
/ microbiology
Female
Fungi
/ genetics
Gastrointestinal Microbiome
Gene Expression Regulation, Bacterial
Gene Expression Regulation, Fungal
Hepatitis, Alcoholic
/ diagnosis
Humans
Intestines
/ microbiology
Male
Metagenome
Metagenomics
Middle Aged
Ribotyping
ITS sequencing
alcoholic hepatitis
mycobiota
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
14 02 2021
14 02 2021
Historique:
received:
23
12
2020
revised:
27
01
2021
accepted:
10
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
1
7
2021
Statut:
epublish
Résumé
Alcohol-related liver disease is one of the most prevalent types of chronic liver diseases globally. Alcohol-related liver disease begins with fatty liver, which further develops into hepatic inflammation, hepatocyte injury, and progresses to fibrosis and cirrhosis. Compositional changes of gut bacteria and fungi were found in patients with alcohol-related liver disease. However, the functional changes of fungi and correlations between fungi and bacteria have not been investigated. In this study, we first examined the functional capacity of fungi in patients with alcohol-related liver disease using shotgun metagenomics. Among 24 MetaCyc pathways contributed by fungi, superpathway of allantoin degradation in yeast was enriched in patients with alcoholic hepatitis. Furthermore, we compared the predictive power of bacteria versus fungi and found that bacteria performed better than fungi to separate patients with alcoholic hepatitis from non-alcoholic controls and patients with alcohol use disorder. Finally, we investigated the associations between the intestinal fungi and bacteria in alcoholic hepatitis patients. Positive association between fungi and bacteria was found between
Identifiants
pubmed: 33672887
pii: toxins13020143
doi: 10.3390/toxins13020143
pmc: PMC7917833
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK120515
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA024726
Pays : United States
Organisme : NIAAA NIH HHS
ID : P50 AA011999
Pays : United States
Organisme : NIAAA NIH HHS
ID : U01 AA026939
Pays : United States
Organisme : NIH HHS
ID : R01 AA24726, R01AA020703, U01 AA026939
Pays : United States
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