Suppressive Role of Bam32/DAPP1 in Chemokine-Induced Neutrophil Recruitment.
Adaptor Proteins, Signal Transducing
/ genetics
Animals
Chemokines
/ genetics
Lipoproteins
/ genetics
Mice
Mice, Knockout
Neutrophil Infiltration
Neutrophils
/ metabolism
Phosphatidylinositol 3-Kinases
/ genetics
Proto-Oncogene Proteins c-akt
/ genetics
Signal Transduction
rho GTP-Binding Proteins
/ genetics
Bam32
CXCL2
neutrophil recruitment
small GTPases
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Feb 2021
12 Feb 2021
Historique:
received:
15
12
2020
revised:
27
01
2021
accepted:
05
02
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
16
4
2021
Statut:
epublish
Résumé
Bam32 (B cell adaptor molecule of 32 kDa) functions in the immune responses of various leukocytes. However, the role of neutrophil Bam32 in inflammation is entirely unknown. Here, we determined the role of Bam32 in chemokine CXCL2-induced neutrophil chemotaxis in three mouse models of neutrophil recruitment. By using intravital microscopy in the mouse cremaster muscle, we found that transmigrated neutrophil number, neutrophil chemotaxis velocity, and total neutrophil chemotaxis distance were increased in Bam32
Identifiants
pubmed: 33673180
pii: ijms22041825
doi: 10.3390/ijms22041825
pmc: PMC7918626
pii:
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Chemokines
0
Dapp1 protein, mouse
0
Lipoproteins
0
Akt2 protein, mouse
EC 2.7.11.1
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
rho GTP-Binding Proteins
EC 3.6.5.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : RGPIN 06611-2018
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