TMS-EEG Co-Registration in Patients with Mild Cognitive Impairment, Alzheimer's Disease and Other Dementias: A Systematic Review.

Alzheimer’s disease brain connectivity electroencephalography plasticity transcranial magnetic stimulation

Journal

Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646

Informations de publication

Date de publication:
27 Feb 2021
Historique:
received: 03 01 2021
revised: 22 02 2021
accepted: 24 02 2021
entrez: 6 3 2021
pubmed: 7 3 2021
medline: 7 3 2021
Statut: epublish

Résumé

An established method to assess effective brain connectivity is the combined use of transcranial magnetic stimulation with simultaneous electroencephalography (TMS-EEG) because TMS-induced cortical responses propagate to distant anatomically connected brain areas. Alzheimer's disease (AD) and other dementias are associated with changes in brain networks and connectivity, but the underlying pathophysiology of these processes is poorly defined. We performed here a systematic review of the studies employing TMS-EEG co-registration in patients with dementias. TMS-EEG studies targeting the motor cortex have revealed a significantly reduced TMS-evoked P30 in AD patients in the temporo-parietal cortex ipsilateral to stimulation side as well as in the contralateral fronto-central area, and we have demonstrated a deep rearrangement of the sensorimotor system even in mild AD patients. TMS-EEG studies targeting other cortical areas showed alterations of effective dorsolateral prefrontal cortex connectivity as well as an inverse correlation between prefrontal-to-parietal connectivity and cognitive impairment. Moreover, TMS-EEG analysis showed a selective increase in precuneus neural activity. TMS-EEG co-registrations can also been used to investigate whether different drugs may affect cognitive functions in patients with dementias.

Identifiants

pubmed: 33673709
pii: brainsci11030303
doi: 10.3390/brainsci11030303
pmc: PMC7997266
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

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Auteurs

Raffaele Nardone (R)

Department of Neurology, Hospital of Merano (SABES-ASDAA), 39012 Merano-Meran, Italy.
Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, 5020 Salzburg, Austria.
Spinal Cord Injury and Tissue Regeneration Center, 5020 Salzburg, Austria.
Karl Landsteiner Institut für Neurorehabilitation und Raumfahrtneurologie, 5020 Salzburg, Austria.

Luca Sebastianelli (L)

Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), 39049 Vipiteno-Sterzing, Italy.
Research Unit for Neurorehabilitation South Tyrol, 39100 Bolzano, Italy.

Viviana Versace (V)

Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), 39049 Vipiteno-Sterzing, Italy.
Research Unit for Neurorehabilitation South Tyrol, 39100 Bolzano, Italy.

Davide Ferrazzoli (D)

Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), 39049 Vipiteno-Sterzing, Italy.
Research Unit for Neurorehabilitation South Tyrol, 39100 Bolzano, Italy.

Leopold Saltuari (L)

Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), 39049 Vipiteno-Sterzing, Italy.
Research Unit for Neurorehabilitation South Tyrol, 39100 Bolzano, Italy.

Eugen Trinka (E)

Department of Neurology, Christian Doppler Klinik, Paracelsus Medical University, 5020 Salzburg, Austria.
Centre for Cognitive Neurosciences Salzburg, 5020 Salzburg, Austria.
University for Medical Informatics and Health Technology, UMIT, 6060 Hall in Tirol, Tirol, Austria.

Classifications MeSH