A Decision Architecture for Safety Computations.

Brain Brain Mapping Humans Magnetic Resonance Imaging Prefrontal Cortex
decision making safety threat ventromedial prefrontal cortex

Journal

Trends in cognitive sciences
ISSN: 1879-307X
Titre abrégé: Trends Cogn Sci
Pays: England
ID NLM: 9708669

Informations de publication

Date de publication:
05 2021
Historique:
received: 11 11 2020
revised: 28 01 2021
accepted: 29 01 2021
pubmed: 7 3 2021
medline: 28 5 2021
entrez: 6 3 2021
Statut: ppublish

Résumé

Accurately estimating safety is critical to pursuing nondefensive survival behaviors. However, little attention has been paid to how the human brain computes safety. We conceptualize a model that consists of two components: (i) threat-oriented evaluations that focus on threat value, imminence, and predictability; and (ii) self-oriented evaluations that focus on the agent's experience, strategies, and ability to control the situation. Our model points to the dynamic interaction between these two components as a mechanism of safety estimation. Based on a growing body of human literature, we hypothesize that distinct regions of the ventromedial prefrontal cortex (vmPFC) respond to threat and safety to facilitate survival decisions. We suggest safety is not an inverse of danger, but reflects independent computations that mediate defensive circuits and behaviors.

Identifiants

DOI: 10.1016/j.tics.2021.01.013 PMID: 33674206 PMC: PMC8035229
pubmed: 33674206
pii: S1364-6613(21)00031-0
doi: 10.1016/j.tics.2021.01.013
pmc: PMC8035229
mid: NIHMS1671275
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

342-354

Subventions

Organisme : NIMH NIH HHS
ID : P50 MH094258
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests No interests are declared.

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Auteurs

Sarah M Tashjian (SM)

Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: smtashji@caltech.edu.

Tomislav D Zbozinek (TD)

Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA.

Dean Mobbs (D)

Humanities and Social Sciences, California Institute of Technology, Pasadena, CA 91125, USA; Computation and Neural Systems, California Institute of Technology, Pasadena, CA 91125, USA.

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Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › A Decision Architecture for Safety Computations.
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Cartographie cérébrale › A Decision Architecture for Safety Computations.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A Decision Architecture for Safety Computations.
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › A Decision Architecture for Safety Computations.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe frontal › Cortex préfrontal › A Decision Architecture for Safety Computations.