Engineered glycomaterial implants orchestrate large-scale functional repair of brain tissue chronically after severe traumatic brain injury.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
27
07
2020
accepted:
21
01
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
19
4
2022
Statut:
epublish
Résumé
Severe traumatic brain injury (sTBI) survivors experience permanent functional disabilities due to significant volume loss and the brain's poor capacity to regenerate. Chondroitin sulfate glycosaminoglycans (CS-GAGs) are key regulators of growth factor signaling and neural stem cell homeostasis in the brain. However, the efficacy of engineered CS (eCS) matrices in mediating structural and functional recovery chronically after sTBI has not been investigated. We report that neurotrophic factor functionalized acellular eCS matrices implanted into the rat M1 region acutely after sTBI significantly enhanced cellular repair and gross motor function recovery when compared to controls 20 weeks after sTBI. Animals subjected to M2 region injuries followed by eCS matrix implantations demonstrated the significant recovery of "reach-to-grasp" function. This was attributed to enhanced volumetric vascularization, activity-regulated cytoskeleton (Arc) protein expression, and perilesional sensorimotor connectivity. These findings indicate that eCS matrices implanted acutely after sTBI can support complex cellular, vascular, and neuronal circuit repair chronically after sTBI.
Identifiants
pubmed: 33674306
pii: 7/10/eabe0207
doi: 10.1126/sciadv.abe0207
pmc: PMC7935369
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NICHD NIH HHS
ID : P2C HD086843
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS099596
Pays : United States
Organisme : NIGMS NIH HHS
ID : R24 GM137782
Pays : United States
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
Références
Magn Reson Med. 2011 Feb;65(2):564-74
pubmed: 20928883
Front Physiol. 2019 Apr 26;10:455
pubmed: 31105581
Neuron. 1999 Nov;24(3):687-700
pubmed: 10595519
Brain Behav Immun. 2017 Nov;66:322-331
pubmed: 28529071
Nat Neurosci. 2009 Jul;12(7):897-904
pubmed: 19483686
Neurology. 2008 Mar 4;70(10):771-8
pubmed: 18316688
Nat Rev Neurosci. 2003 Jun;4(6):456-68
pubmed: 12778118
Tissue Eng Part A. 2013 Sep;19(17-18):1909-18
pubmed: 23596981
Brain Res Bull. 2019 Aug;150:136-149
pubmed: 31128250
Magn Reson Imaging. 2007 Feb;25(2):219-27
pubmed: 17275617
Adv Pharmacol. 2006;53:253-79
pubmed: 17239770
Curr Opin Neurobiol. 2005 Feb;15(1):116-20
pubmed: 15721753
J Neurol Neurosurg Psychiatry. 1992 May;55(5):362-8
pubmed: 1602308
Adv Healthc Mater. 2020 Mar;9(5):e1900285
pubmed: 31977165
J Biophotonics. 2015 Jun;8(6):502-11
pubmed: 25196192
Annu Rev Cell Biol. 1988;4:229-55
pubmed: 3143379
Stem Cells. 2010 Apr;28(4):775-87
pubmed: 20087964
Biomaterials. 2017 Sep;140:88-102
pubmed: 28641124
J Neurotrauma. 1994 Apr;11(2):187-96
pubmed: 7932797
Development. 2007 Aug;134(15):2727-38
pubmed: 17596283
J Biol Chem. 1998 Aug 21;273(34):21439-42
pubmed: 9705269
J Neurotrauma. 2016 Jan 15;33(2):215-25
pubmed: 26159676
Glycoconj J. 2013 Aug;30(6):619-32
pubmed: 23275130
Nat Mater. 2018 Jul;17(7):642-651
pubmed: 29784996
Biomed Rep. 2013 Mar;1(2):167-176
pubmed: 24648914
Curr Opin Biotechnol. 2016 Aug;40:155-163
pubmed: 27162093
PLoS One. 2013 Sep 30;8(9):e74405
pubmed: 24098645
J Neurosurg. 2004 Jan;100(1):88-96
pubmed: 14743917
Acta Radiol. 1993 Nov;34(6):593-9
pubmed: 8240895
Brain. 2007 Nov;130(Pt 11):2962-76
pubmed: 17728358
Biomaterials. 2001 May;22(10):1113-23
pubmed: 11352091
J Neurochem. 1972 Oct;19(10):2325-32
pubmed: 4658791
J Rehabil Med. 2003 May;(41 Suppl):7-10
pubmed: 12817650
Restor Neurol Neurosci. 2011;29(4):215-25
pubmed: 21697596
Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18430-5
pubmed: 22025720
Biomaterials. 2010 May;31(14):3840-7
pubmed: 20185173
J Cereb Blood Flow Metab. 2000 Jun;20(6):921-30
pubmed: 10894175
Pediatr Crit Care Med. 2015 Mar;16(3):245-55
pubmed: 25581630
Bioconjug Chem. 2015 Dec 16;26(12):2336-49
pubmed: 26440046
Stroke. 2009 Apr;40(4):1490-5
pubmed: 19164786
Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11370-5
pubmed: 16837575
Methods Enzymol. 2010;479:37-71
pubmed: 20816159
Stem Cells. 2008 Mar;26(3):798-809
pubmed: 18079434
J Nucl Med. 1994 Feb;35(2):217-26
pubmed: 8294988
Nat Med. 2018 Aug;24(8):1257-1267
pubmed: 29915259
J Neurol Neurosurg Psychiatry. 1992 Jun;55(6):475-80
pubmed: 1619415
J Clin Invest. 2003 Oct;112(8):1202-10
pubmed: 14561705
Trends Neurosci. 2008 Mar;31(3):146-53
pubmed: 18255164
Front Mol Neurosci. 2010 Feb 09;3:1
pubmed: 20162032
Tissue Eng. 2005 Mar-Apr;11(3-4):513-25
pubmed: 15869430
Nat Methods. 2019 Jul;16(7):565-566
pubmed: 31217592
Contrast Media Mol Imaging. 2015 Jan-Feb;10(1):43-50
pubmed: 24764174
Neurosci Lett. 2015 Jun 26;598:96-101
pubmed: 25980992
Mol Neurobiol. 2017 Jan;54(1):661-670
pubmed: 26758277
J Biol Chem. 2006 Mar 3;281(9):5982-91
pubmed: 16373347
J Neuroimmune Pharmacol. 2014 Mar;9(2):92-101
pubmed: 24057103
Biomaterials. 2012 Sep;33(26):5983-96
pubmed: 22681976
J Neurotrauma. 2010 Aug;27(8):1399-411
pubmed: 20528163
Brain Behav Immun. 2012 Nov;26(8):1191-201
pubmed: 22728326
J Neurosci. 2018 Jan 3;38(1):93-107
pubmed: 29133435
ACS Biomater Sci Eng. 2017 Mar 13;3(3):420-430
pubmed: 29744379
Neuroscience. 2004;125(1):129-39
pubmed: 15051152
J Biol Chem. 2002 Nov 15;277(46):43707-16
pubmed: 12221095
Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13444-9
pubmed: 21808045
Nature. 2005 Jul 14;436(7048):266-71
pubmed: 16015332
J Biol Chem. 2012 Apr 20;287(17):13822-8
pubmed: 22389491
Nat Chem Biol. 2006 Sep;2(9):467-73
pubmed: 16878128
Eur J Neurosci. 2006 Aug;24(3):739-49
pubmed: 16930404
Trends Neurosci. 2018 Jan;41(1):47-61
pubmed: 29150096
Biomaterials. 2012 Mar;33(7):2067-75
pubmed: 22169139
Dis Model Mech. 2009 Jan-Feb;2(1-2):23-38
pubmed: 19132123
Stem Cells Int. 2018 Aug 5;2018:5024175
pubmed: 30154864
Curr Opin Neurobiol. 2006 Dec;16(6):638-44
pubmed: 17084614
Nat Med. 2013 Aug;19(8):998-1004
pubmed: 23921754
Brain Behav. 2019 Mar;9(3):e01214
pubmed: 30747485
Cell. 2014 Nov 6;159(4):896-910
pubmed: 25417164
J Neurotrauma. 2005 Dec;22(12):1411-8
pubmed: 16379579
Neurosci Biobehav Rev. 2004 Jul;28(4):365-78
pubmed: 15341032