Neoadjuvant Chemotherapy Induces IL34 Signaling and Promotes Chemoresistance via Tumor-Associated Macrophage Polarization in Esophageal Squamous Cell Carcinoma.

Aged Antigens, CD / metabolism Antigens, Differentiation, Myelomonocytic / metabolism Antineoplastic Combined Chemotherapy Protocols / therapeutic use Carcinoma, Squamous Cell / drug therapy Cell Line, Tumor Cisplatin / administration & dosage Drug Resistance, Neoplasm / genetics Esophageal Neoplasms / drug therapy Female Fluorouracil / administration & dosage Gene Expression Regulation, Neoplastic / drug effects Humans Interleukins / genetics Kaplan-Meier Estimate Macrophage Activation / drug effects Male Middle Aged Neoadjuvant Therapy / methods Receptors, Cell Surface / metabolism Signal Transduction / drug effects Tumor Microenvironment / drug effects Tumor-Associated Macrophages / classification

Journal

Molecular cancer research : MCR

ISSN: 1557-3125

Titre abrégé: Mol Cancer Res

Pays: United States

ID NLM: 101150042

Informations de publication

Date de publication:
06 2021

Historique:

received: 15 10 2020

revised: 26 01 2021

accepted: 02 03 2021

pubmed: 7 3 2021

medline: 27 1 2022

entrez: 6 3 2021

Statut: ppublish

Résumé

The tumor microenvironment (TME) plays a key role in the efficacy of neoadjuvant chemotherapy (NAC) in solid tumors including esophageal squamous cell carcinoma (ESCC). However, the TME profile of ESCC treated with NAC is not fully understood. In this study, we investigated the effect of NAC on the TME especially tumor-associated macrophages (TAM), the important immunosuppressive components of the TME, in ESCC. We quantified the expression of CD163, a crucial marker of TAM, in pretherapeutic biopsy and surgically resected ESCC specimens from patients who received NAC (

Identifiants

DOI: 10.1158/1541-7786.MCR-20-0917 PMID: 33674443

pubmed: 33674443

pii: 1541-7786.MCR-20-0917

doi: 10.1158/1541-7786.MCR-20-0917

doi:

Substances chimiques

Antigens, CD 0

Antigens, Differentiation, Myelomonocytic 0

CD163 antigen 0

IL34 protein, human 0

Interleukins 0

Receptors, Cell Surface 0

Cisplatin Q20Q21Q62J

Fluorouracil U3P01618RT

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

1085-1095

Informations de copyright

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