Proteomics of REPLICANT perfusate detects changes in the metastatic lymph node microenvironment.
Journal
NPJ breast cancer
ISSN: 2374-4677
Titre abrégé: NPJ Breast Cancer
Pays: United States
ID NLM: 101674891
Informations de publication
Date de publication:
05 Mar 2021
05 Mar 2021
Historique:
received:
20
07
2020
accepted:
20
01
2021
entrez:
6
3
2021
pubmed:
7
3
2021
medline:
7
3
2021
Statut:
epublish
Résumé
In breast cancer (BC), detecting low volumes of axillary lymph node (ALN) metastasis pre-operatively is difficult and novel biomarkers are needed. We recently showed that patient-derived ALNs can be sustained ex-vivo using normothermic perfusion. We now compare reactive (tumour-free; n = 5) and macrometastatic (containing tumour deposits >2 mm; n = 4) ALNs by combining whole section multiplex immunofluorescence with TMT-labelled LC-MS/MS of the circulating perfusate. Macrometastases contained significantly fewer B cells and T cells (CD4
Identifiants
pubmed: 33674617
doi: 10.1038/s41523-021-00227-7
pii: 10.1038/s41523-021-00227-7
pmc: PMC7935848
doi:
Types de publication
Journal Article
Langues
eng
Pagination
24Subventions
Organisme : Cancer Research UK (CRUK)
ID : CRC598X
Organisme : Cancer Research UK (CRUK)
ID : Pioneer Award CRC598X
Organisme : Cancer Research UK (CRUK)
ID : Pioneer Award CRC598X
Références
Nature. 2016 May 25;534(7605):55-62
pubmed: 27251275
J Immunol. 1996 Jul 15;157(2):495-9
pubmed: 8752893
Shock. 2014 Dec;42(6):485-498
pubmed: 25243428
BMC Cancer. 2019 Aug 23;19(1):831
pubmed: 31443698
Nature. 2019 Feb;566(7745):553-557
pubmed: 30728496
J Pathol. 2012 Apr;226(5):756-63
pubmed: 22081483
NPJ Breast Cancer. 2021 Mar 5;7(1):24
pubmed: 33674617
Nat Genet. 2018 May;50(5):645-651
pubmed: 29610475
Clin Cancer Res. 2018 Oct 1;24(19):4763-4770
pubmed: 29891724
Adv Biol Regul. 2012 May;52(2):326-39
pubmed: 22781746
Nat Rev Drug Discov. 2009 Aug;8(8):627-44
pubmed: 19644473
Biochim Biophys Acta. 2016 Jan;1865(1):3-13
pubmed: 26071879
Surgeon. 2017 Apr;15(2):76-82
pubmed: 27498412
Clin Chem. 2002 Aug;48(8):1296-304
pubmed: 12142387
Cancers (Basel). 2017 Aug 23;9(9):
pubmed: 28832494
Physiol Rev. 2012 Jul;92(3):1005-60
pubmed: 22811424
N Engl J Med. 2018 Nov 29;379(22):2108-2121
pubmed: 30345906
Cell Rep. 2019 Nov 26;29(9):2810-2822.e5
pubmed: 31775047
J Proteomics. 2013 Jan 14;78:172-87
pubmed: 23202415
Ann Oncol. 2018 Nov 1;29(11):2232-2239
pubmed: 30203045
Proteomics. 2008 Dec;8(23-24):5038-52
pubmed: 19003862
Oncoimmunology. 2016 Dec 14;6(1):e1257452
pubmed: 28197375
Proteomics. 2004 Mar;4(3):753-65
pubmed: 14997497
Eur J Cancer. 2019 Jun;114:76-88
pubmed: 31075727
Int J Mol Sci. 2019 Oct 07;20(19):
pubmed: 31591367
Proteomics Clin Appl. 2018 May;12(3):e1700117
pubmed: 29384592
Oncol Rep. 2011 Jul;26(1):185-91
pubmed: 21503584
J Transl Med. 2009 Jul 13;7:60
pubmed: 19594898
Cancer Genomics Proteomics. 2015 Mar-Apr;12(2):89-101
pubmed: 25770193
Nat Rev Cancer. 2003 Jun;3(6):453-8
pubmed: 12778135
Immunity. 2018 Mar 20;48(3):434-452
pubmed: 29562194
Nature. 2003 Oct 16;425(6959):737-41
pubmed: 14562106
Breast. 2013 Dec;22(6):1226-7
pubmed: 23988396
Nature. 2012 Oct 4;490(7418):61-70
pubmed: 23000897
J Clin Pathol. 2020 Sep;73(9):557-562
pubmed: 31969377
Adv Anat Pathol. 2017 Sep;24(5):235-251
pubmed: 28777142
Nucleic Acids Res. 2011 Jan;39(Database issue):D712-7
pubmed: 21071422
J Pathol. 2020 Mar;250(3):262-274
pubmed: 31755096
Cancer Discov. 2013 Oct;3(10):1108-12
pubmed: 24124232
J Clin Oncol. 2018 Jun 1;36(16):1631-1641
pubmed: 29504847
Nat Rev Immunol. 2015 Jun;15(6):350-61
pubmed: 25998961
J Cancer. 2017 Sep 2;8(15):3062-3069
pubmed: 28928897
Cancer Res. 2010 Apr 15;70(8):3042-51
pubmed: 20388801
Nat Rev Clin Oncol. 2019 Jun;16(6):356-371
pubmed: 30705439
Clin Cancer Res. 2009 Aug 1;15(15):4799-805
pubmed: 19638457
Ann Surg. 2010 Sep;252(3):426-32; discussion 432-3
pubmed: 20739842
N Engl J Med. 2009 Aug 13;361(7):653-63
pubmed: 19675329
Anat Rec (Hoboken). 2011 Nov;294(11):1818-24
pubmed: 21964916
J Proteome Res. 2015 Jun 5;14(6):2707-13
pubmed: 25873244
J Exp Med. 2019 May 6;216(5):1091-1107
pubmed: 30975896
Mediators Inflamm. 2019 Mar 10;2019:8968943
pubmed: 30983883
Anal Chem. 2004 Jul 15;76(14):4193-201
pubmed: 15253663
Nat Med. 2018 Dec;24(12):1852-1858
pubmed: 30478423
Lancet. 2017 Jun 17;389(10087):2403-2414
pubmed: 27939057
Proteomes. 2013 Aug 27;1(2):109-127
pubmed: 28250400
J Biol Chem. 2005 Feb 11;280(6):4544-52
pubmed: 15590642
Nat Methods. 2009 May;6(5):359-62
pubmed: 19377485
Front Oncol. 2017 Feb 02;7:14
pubmed: 28210565
Gut. 2019 Apr;68(4):742-758
pubmed: 30396902
Nat Cell Biol. 2019 Jul;21(7):879-888
pubmed: 31263265
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9042-7
pubmed: 23671068
Neoplasia. 2018 Feb;20(2):140-151
pubmed: 29248718
Nat Rev Cancer. 2009 Apr;9(4):285-93
pubmed: 19308068
J Cell Biol. 2012 Feb 20;196(4):395-406
pubmed: 22351925
Cell Syst. 2016 Mar 23;2(3):172-84
pubmed: 27135363
Cancer Res. 2006 Dec 15;66(24):11825-30
pubmed: 17178879
J Natl Cancer Inst. 2010 Mar 17;102(6):410-25
pubmed: 20190185