The Effect of Pulsed Electromagnetic Fields on Angiogenesis.
angiogenesis
endothelial cells
growth factor
pulsed electromagnetic field (PEMF)
Journal
Bioelectromagnetics
ISSN: 1521-186X
Titre abrégé: Bioelectromagnetics
Pays: United States
ID NLM: 8008281
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
revised:
03
02
2021
received:
08
12
2020
accepted:
21
02
2021
pubmed:
7
3
2021
medline:
26
10
2021
entrez:
6
3
2021
Statut:
ppublish
Résumé
A pulsed electromagnetic field (PEMF) has been used to treat inflammation-based diseases such as osteoporosis, neurological injury, and osteoarthritis. Numerous animal experiments and in vitro studies have shown that PEMF may affect angiogenesis. For ischemic diseases, in theory, blood flow may be richer by increasing the number of blood vessels which supply blood to ischemic tissue. PEMF plays a role in enhancing angiogenesis, and their clinical application may go far beyond the current scope. In this review, we analyzed and summarized the effects and possible mechanisms of PEMF on angiogenesis. Most studies have shown that PEMF with specific parameters can promote angiogenesis, which is manifested by an increased vascular growth rate and increased capillary density. The potential mechanisms consist of promoting vascular endothelial cell proliferation, migration, and tube formation, and increasing the expression level of vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF2), angiopoietin-2 (Ang-2), and other angiogenic growth factors. Additionally, PEMF has an impact on the activation of voltage-gated calcium channels (VGCC). Bioelectromagnetics. © 2021 Bioelectromagnetics Society.
Substances chimiques
Vascular Endothelial Growth Factor A
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
250-258Subventions
Organisme : the Project of the Science and Technology Department in Sichuan province
ID : 2019YJ0119
Organisme : the National Natural Science Foundation of China
ID : 81572231
Informations de copyright
© 2021 Bioelectromagnetics Society.
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