Expression quantitative trait loci of genes predicting outcome are associated with survival of multiple myeloma patients.

Aged Apyrase / genetics Female Gene Expression Profiling / methods Genetic Association Studies Germ-Line Mutation Humans Male Middle Aged Mitochondrial Proteins / genetics Multiple Myeloma / genetics Polymorphism, Single Nucleotide Quantitative Trait Loci RNA-Binding Proteins / genetics Survival Analysis
eQTL genetic polymorphisms multiple myeloma overall survival progression-free survival

Journal

International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124

Informations de publication

Date de publication:
15 07 2021
Historique:
revised: 30 11 2020
received: 15 04 2020
accepted: 14 12 2020
pubmed: 7 3 2021
medline: 8 9 2021
entrez: 6 3 2021
Statut: ppublish

Résumé

Gene expression profiling can be used for predicting survival in multiple myeloma (MM) and identifying patients who will benefit from particular types of therapy. Some germline single nucleotide polymorphisms (SNPs) act as expression quantitative trait loci (eQTLs) showing strong associations with gene expression levels. We performed an association study to test whether eQTLs of genes reported to be associated with prognosis of MM patients are directly associated with measures of adverse outcome. Using the genotype-tissue expression portal, we identified a total of 16 candidate genes with at least one eQTL SNP associated with their expression with P < 10

Identifiants

DOI: 10.1002/ijc.33547 PMID: 33675538 PMC: PMC8770990
pubmed: 33675538
doi: 10.1002/ijc.33547
pmc: PMC8770990
mid: NIHMS1762265
doi:

Substances chimiques

Mitochondrial Proteins 0
RNA-Binding Proteins 0
TBRG4 protein, human 0
Apyrase EC 3.6.1.5
ENTPD1 protein, human EC 3.6.1.5

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

327-336

Subventions

Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : R25 CA092049
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA118948
Pays : United States
Organisme : the National Institute of Health/National Cancer Institute
ID : P30 CA13148
Organisme : NCI NIH HHS
ID : P30 CA013148
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA186646
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA134674
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA107476
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA155951
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA235026
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA168762
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA186781
Pays : United States
Organisme : NCI NIH HHS
ID : R25 CA047888
Pays : United States
Organisme : Wellcome Trust
ID : 209057
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA042014
Pays : United States

Informations de copyright

© 2021 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of Union for International Cancer Control.

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Auteurs

Angelica Macauda (A)

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Department of Biology, University of Pisa, Pisa, Italy.
ORCID: 0000-0001-9820-5079

Chiara Piredda (C)

Department of Biology, University of Pisa, Pisa, Italy.

Alyssa I Clay-Gilmour (AI)

Department of Epidemiology & Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.

Juan Sainz (J)

Genomic Oncology Area, GENYO. Centre for Genomics and Oncological Research: Pfizer, University of Granada/Andalusian Regional Government, Granada, Spain.
Hematology department, Virgen de las Nieves University Hospital, Granada, Spain.
ORCID: 0000-0002-9355-2423

Gabriele Buda (G)

Clinical and Experimental Medicine, Section of Hematology, University of Pisa, Pisa, Italy.

Miroslaw Markiewicz (M)

Department of Hematology and Bone Marrow Transplantation, SPSKM Hospital, Katowice, Poland.

Torben Barington (T)

Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.

Elad Ziv (E)

Department of Medicine, Division of General Internal Medicine, Institute for Human Genetics, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, USA.

Michelle A T Hildebrandt (MAT)

Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
ORCID: 0000-0001-6769-6872

Alem A Belachew (AA)

Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Judit Varkonyi (J)

Third Department of Internal Medicine, Semmelweis University, Budapest, Hungary.

Witold Prejzner (W)

Department of Hematology and Transplantation, Medical University of Gdansk, Gdansk, Poland.

Agnieszka Druzd-Sitek (A)

Department of Lymphoid Malignacies, Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland.

John Spinelli (J)

Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada.
School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.

Niels Frost Andersen (NF)

Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.

Jonathan N Hofmann (JN)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

Marek Dudziński (M)

Department of Hematology, Institute of Medical Sciences, College of Medical Sciences, University of Rzeszow, Rzeszow, Poland.

Joaquin Martinez-Lopez (J)

Complutense University, CNIO, CIBERONC, Hospital 12 de Octubre, Madrid, Spain.

Elzbieta Iskierka-Jazdzewska (E)

Department of Haematology, Copernicus Memorial Hospital, Lodz, Poland.

Roger L Milne (RL)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.

Grzegorz Mazur (G)

Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, Wroclaw, Poland.

Graham G Giles (GG)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.

Lene Hyldahl Ebbesen (LH)

Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.

Marcin Rymko (M)

Department of Hematology, N. Copernicus Town Hospital, Torun, Poland.

Krzysztof Jamroziak (K)

Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.

Edyta Subocz (E)

Department of Haematology, Military Institute of Medicine, Warsaw, Poland.

Rui Manuel Reis (RM)

Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.
Molecular Oncology Research Center, Barretos, São Paulo, Brazil.

Ramon Garcia-Sanz (R)

Department of Hematology, University Hospital of Salamanca, IBSAL, Salamanca, Spain.

Anna Suska (A)

Department of Hematology, Jagiellonian University Medical College, Cracow, Poland.

Eva Kannik Haastrup (EK)

Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Daria Zawirska (D)

Department of Hematology, University Hospital of Cracow, Cracow, Poland.

Norbert Grzasko (N)

Department of Experimental Hematooncolog, Medical University of Lublin, Lublin, Poland.
Department of Hematology, St. John's Cancer Center, Lublin, Poland.

Annette Juul Vangsted (AJ)

Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Charles Dumontet (C)

Cancer Research Center of Lyon/Hospices Civils de Lyon, Lyon, France.

Marcin Kruszewski (M)

Department of Hematology, University Hospital Bydgoszcz, Bydgoszcz, Poland.

Magdalena Dutka (M)

Department of Hematology and Transplantation, Medical University of Gdansk, Gdansk, Poland.

Nicola J Camp (NJ)

University of Utah, Salt Lake City, Utah, USA.

Rosalie G Waller (RG)

University of Utah, Salt Lake City, Utah, USA.

Waldemar Tomczak (W)

Medical University of Lublin, Lublin, Poland.

Matteo Pelosini (M)

Clinical and Experimental Medicine, Section of Hematology, University of Pisa, Pisa, Italy.

Małgorzata Raźny (M)

Department of Hematology, Rydygier Specialistic Hospital, Cracow, Poland.

Herlander Marques (H)

Molecular Oncology Research Center, Barretos, São Paulo, Brazil.

Niels Abildgaard (N)

Department of Hematology, Odense University Hospital, Odense, Denmark.

Marzena Wątek (M)

Hematology Clinic, Holycross Cancer Center, Kielce, Poland.

Artur Jurczyszyn (A)

Department of Hematology, Jagiellonian University Medical College, Cracow, Poland.

Elizabeth E Brown (EE)

Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Sonja Berndt (S)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

Aleksandra Butrym (A)

Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, Wroclaw, Poland.

Celine M Vachon (CM)

Genetic Epidemiology and Risk Assessment Program, Mayo Clinic Comprehensive Cancer Center, and Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.

Aaron D Norman (AD)

Genetic Epidemiology and Risk Assessment Program, Mayo Clinic Comprehensive Cancer Center, and Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.

Susan L Slager (SL)

Genetic Epidemiology and Risk Assessment Program, Mayo Clinic Comprehensive Cancer Center, and Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.

Federica Gemignani (F)

Department of Biology, University of Pisa, Pisa, Italy.

Federico Canzian (F)

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0002-4261-4583

Daniele Campa (D)

Department of Biology, University of Pisa, Pisa, Italy.
ORCID: 0000-0003-3220-9944

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Expression quantitative trait loci of genes...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Acid anhydride hydrolases › Apyrase › Expression quantitative trait loci of genes...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Expression quantitative trait loci of genes...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Études d'associations génétiques › Expression quantitative trait loci of genes...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation germinale › Expression quantitative trait loci of genes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Expression quantitative trait loci of genes...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Expression quantitative trait loci of genes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Expression quantitative trait loci of genes...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Paraprotéinémies › Myélome multiple › Expression quantitative trait loci of genes...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Expression quantitative trait loci of genes...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › Expression quantitative trait loci of genes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Expression quantitative trait loci of genes...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Expression quantitative trait loci of genes...