Reduced sarcoplasmic reticulum Ca
Asthma
Biomarkers
Oxidative stress
SERCA dysfunction
Skeletal muscle
Journal
Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521
Informations de publication
Date de publication:
15 May 2021
15 May 2021
Historique:
received:
16
01
2021
revised:
10
02
2021
accepted:
20
02
2021
pubmed:
7
3
2021
medline:
10
4
2021
entrez:
6
3
2021
Statut:
ppublish
Résumé
Skeletal muscle mass and strength are reduced in asthma and contribute to compromised functional capacity in asthmatic patients. However, an effective pharmacological intervention remains elusive, partly because molecular mechanisms dictating muscle decline in asthma are not known. We investigated the potential contribution(s) of skeletal muscle sarcoplasmic reticulum Ca Maximal SERCA activity was reduced in skeletal muscles of mild and advanced asthmatics and was associated with reduced expression of SERCA2 protein and upregulation of sarcolipin, a SERCA inhibitory lipoprotein. We also found downregulation of Ca Taken together, our data suggest that muscle weakness and atrophy in asthma is in part driven by SERCA dysfunction and oxidative stress. The data propose SERCA dysfunction as a therapeutic intervention to address muscle decline in asthma.
Identifiants
pubmed: 33675897
pii: S0024-3205(21)00281-2
doi: 10.1016/j.lfs.2021.119296
pii:
doi:
Substances chimiques
Biomarkers
0
Sarcoplasmic Reticulum Calcium-Transporting ATPases
EC 3.6.3.8
ATP2A2 protein, human
EC 7.2.2.10
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
119296Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.