Hydrochlorothiazide-induced hepatotoxicity: A rare case of DILI.

Aged, 80 and over Biopsy Chemical and Drug Induced Liver Injury / diagnosis Diagnosis, Differential Female Humans Hydrochlorothiazide / adverse effects
Acute hepatitis DILI Hepatotoxicity Hydrochlorothiazide Thiazide diuretics

Journal

Clinics and research in hepatology and gastroenterology
ISSN: 2210-741X
Titre abrégé: Clin Res Hepatol Gastroenterol
Pays: France
ID NLM: 101553659

Informations de publication

Date de publication:
09 2021
Historique:
received: 04 12 2020
accepted: 12 12 2020
pubmed: 7 3 2021
medline: 14 1 2022
entrez: 6 3 2021
Statut: ppublish

Résumé

Thiazide diuretics are prescribed daily and rarely hepatotoxic. We report the case of 86-year-old woman who was admitted in hospital for jaundice after taking hydrochlorothiazide. All differential diagnoses have been eliminated. The liver biopsy was compatible with drug-induced hepatitis. Clinical and biological manifestations improved after discontinuation of the treatment. The reported case is compared to three other cases in the literature.

Identifiants

DOI: 10.1016/j.clinre.2020.101599 PMID: 33676268
pubmed: 33676268
pii: S2210-7401(20)30365-X
doi: 10.1016/j.clinre.2020.101599
pii:
doi:

Substances chimiques

Hydrochlorothiazide 0J48LPH2TH

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

101599

Informations de copyright

Copyright © 2020 Elsevier Masson SAS. All rights reserved.

Auteurs

Emilie Malézieux (E)

Liver and Transplantation Unit, St-Eloi University Hospital, Montpellier, France.

Lucy Meunier (L)

Liver and Transplantation Unit, St-Eloi University Hospital, Montpellier, France. Electronic address: lucy.meunier@chu-montpellier.fr.

Benjamin Rivière (B)

Department of Pathology, St-Eloi University Hospital, Montpellier, France.

Dominique Larrey (D)

Liver and Transplantation Unit, St-Eloi University Hospital, Montpellier, France.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Hydrochlorothiazide-induced hepatotoxicity: A...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytodiagnostic › Biopsie › Hydrochlorothiazide-induced hepatotoxicity: A...
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Lésions hépatiques dues aux substances › Hydrochlorothiazide-induced hepatotoxicity: A...
questionsmedicales.fr › Diagnostic › Diagnostic différentiel › Hydrochlorothiazide-induced hepatotoxicity: A...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hydrochlorothiazide-induced hepatotoxicity: A...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzothiadiazines › Chlorothiazide › Hydrochlorothiazide › Hydrochlorothiazide-induced hepatotoxicity: A...