Emerging cell biological functions of phosphatidylinositol 5 phosphate 4 kinase.
Autophagy
Class I PI3K
Endocytosis
PI5P
PIP4K
Receptor tyrosine kinase signaling
Journal
Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
15
12
2020
revised:
19
01
2021
accepted:
30
01
2021
pubmed:
8
3
2021
medline:
27
10
2021
entrez:
7
3
2021
Statut:
ppublish
Résumé
The generation of phosphoinositides (PIs) with spatial and temporal control is a key mechanism in cellular organization and signaling. The synthesis of PIs is mediated by PI kinases, proteins that are able to phosphorylate unique substrates at specific positions on the inositol headgroup to generate signaling molecules. Phosphatidylinositol 5 phosphate 4 kinase (PIP4K) is one such lipid kinase that is able to specifically phosphorylate phosphatidylinositol 5 phosphate, the most recently discovered PI to generate the well-known and abundant PI, phosphatidylinositol 4,5 bisphosphate [PI(4,5)P
Identifiants
pubmed: 33677148
pii: S0955-0674(21)00018-1
doi: 10.1016/j.ceb.2021.01.012
pmc: PMC7611344
mid: EMS130518
pii:
doi:
Substances chimiques
Phosphates
0
Phosphatidylinositols
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
15-20Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : DBT-Wellcome Trust India Alliance
ID : IA/S/14/2/501540
Pays : India
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest statement Nothing declared.